DM Pharmacology Flashcards
empiric treatment
treat based off suspicion of what could be causing symptoms
What 3 drugs increase insulin secretion from pancreas?
sulfonylureas
meglitinides
DPP-4
What class of drugs is Metform?
antihyperglycemics / biguanides
What class of drug inhibits hepatic glucose production?
antihyperglycemic / biguanides
What class of drugs inhibits dietary uptake of glucose?
alpha - glucosidase
Which class of drugs inhibits renal recovery of glucose from filtrate ?
SGLT2 inhibitors
What class of drugs increases insulin sensitivity ?
thiazolidinediones
MOA of sulfonylurea + meglitinides
interact with K+ channels on B-cells
cause K+ channels to close and trigger insulin release
MOA of DPP-4 inhibitors
inhibits the DPP-4 protease that usually breaks down incretins
incretins trigger insulin release
by inhibiting break down of incretins, you have longer insulin release
examples of incretins
GIP and GLP-1
Metformin MOA
inhibits gluconeogenesis
inhibit the ETC which increases AMP
increased AMP decreases FBP-1 activity and increasing PFK-1 activity
FBP-1
when active, it increases gluconeogenesis
metformin and FBP-1
inhibits FBP-1 through decreasing AMP levels
downregulates gluconeogenesis
SGLT-1
synporter with Na+ for glucose
found in liver
SGLT-2
synporter with Na+ for glucose
found in kidneys
