Thyroid Pharm Flashcards
__ is the major thyroid hormone replacement drug because of its
T4 Levothyroxine; longer half life
T3 is only used for
myxedema coma (severe hypothyroidism)
Side effects for thyroid hormone replacements are due to
inappropriate dosing
Give __ dose of thyroid hormone in older patients bc
less; they don’t clear it well
Two common ions that decrease LT4 absorption
iron, calcium
Condition that decreases LT4 absorption
small intestinal disease
Increased TSH on therapy may be due to
increased TBG
This NT and high dose ___ lower TSH
dopamine, glucocorticoids
Self administration of ___ can cause low TSH
LT4
Two situations where TSH is very important
pregnancy, thyroid cancer
Antithyroid drugs take ___ to start working
2-4 weeks
PTU is ___ bound and decreases __ to _ converstion
protein; T4-T3
Use methimazole in all Grave’s disease patients except
first trimester of pregnancy, thyroid storm, adverse rxn to methimazole
Major side effect of antithyroid drugs
Agranulocytosis
Severe hepatitis is a severe side effect of
PTU