Thyroid Pharm Flashcards

1
Q

__ is the major thyroid hormone replacement drug because of its

A

T4 Levothyroxine; longer half life

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2
Q

T3 is only used for

A

myxedema coma (severe hypothyroidism)

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3
Q

Side effects for thyroid hormone replacements are due to

A

inappropriate dosing

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4
Q

Give __ dose of thyroid hormone in older patients bc

A

less; they don’t clear it well

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5
Q

Two common ions that decrease LT4 absorption

A

iron, calcium

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6
Q

Condition that decreases LT4 absorption

A

small intestinal disease

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7
Q

Increased TSH on therapy may be due to

A

increased TBG

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8
Q

This NT and high dose ___ lower TSH

A

dopamine, glucocorticoids

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9
Q

Self administration of ___ can cause low TSH

A

LT4

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10
Q

Two situations where TSH is very important

A

pregnancy, thyroid cancer

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11
Q

Antithyroid drugs take ___ to start working

A

2-4 weeks

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12
Q

PTU is ___ bound and decreases __ to _ converstion

A

protein; T4-T3

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13
Q

Use methimazole in all Grave’s disease patients except

A

first trimester of pregnancy, thyroid storm, adverse rxn to methimazole

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14
Q

Major side effect of antithyroid drugs

A

Agranulocytosis

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15
Q

Severe hepatitis is a severe side effect of

A

PTU

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16
Q

Use ____ to thyrotoxicosis of any etiology

A

Beta Blockers

17
Q

Use __ in subacute thyroidosis

A

NSAIDS

18
Q

Wolff-Chaikoff Effect

What it is and how it affects normal and abnormal thyroids

A

• Excess iodide transiently inhibits thyroid
iodide organification (step 2)
– In individuals with a normal thyroid, the
gland escapes from this inhibitory effect
– In individuals with underlying autoimmune
thyroid disease (Hashimoto’s thyroiditis or
Graves’ disease), the suppressive effect
may persist

19
Q

Jod-Basedow Phenomenon

What it is and when it occurs

A

Thyrotoxicosis produced by iodine
exposure
• Occurs in nodular thyroid glands

20
Q

Radioiodine low and high dose purposes

A

Low- diagnostics

high- therapeutics

21
Q

Amiodarone is used for arrhythmias, but can cause hyperthyroidism in two types. Describe them

A

Type 1 in patients with underlying thyroid nodular
disease or Graves’ disease—increased thyroid
hormone production, Iodine effect
Type 2 in patients with normal thyroids—
destructive thyroiditis— increased thyroid hormone
release, Direct toxic effect of amiodarone.