Pathophysiology and Pharmacology of Pituitary

Question 1

Only a disease of the ___ can suppress vasopressin and cause __ __

Answer 1

infundibulum; diabetes insipidus

Question 2

Growth hormone deficiencies cause short stature because of ___ ___, decreased __ and increased __, and decreased (bone)

Answer 2

epiphyseal closure; muscle; fat; bone mineral density

Question 3

Hypersecretion of hormones can only come from pituitary

Answer 3

pituitary adenomas

Question 4

The __ hormone producing hormones tend to make people look funny/have clinical symptoms

Answer 4

peptide

Question 5

Two clinical syndromes from somatotroph adenomas- before and after epiphyseal closure

Answer 5

before- gigantism

after- acromegaly (everything grows except the long bones)

Question 6

Diagnosing somatotroph adenoma chemically

Answer 6

Increased IGF-1 in serum and lack of GH suppression to oral glucose

Question 7

SOMATOTROPH ADENOMA is a risk factor for ___ cancer

Answer 7

colon

Question 8

Bone overgrowth because of SOMATOTROPH ADENOMA can cause

Answer 8

osteoarthritis

Question 9

____ agonists paradoxically decrease GH release from SOMATOTROPH ADENOMA

Answer 9

dopamine

Question 10

Analogs of ___ can act as negative feedback on somatotroph cells

Answer 10

somatostatin

Question 11

PEGVISOMANT, an __ __ receptor antagonist, only binds one ___ of the receptor in order to block but not activate

Answer 11

GH; domain

Question 12

Symptoms of Lactotroph adenomas in pre vs post menopausal woman

Answer 12

Pre- oligo/amenorrhea and galactorrhea

Post- neurological symptoms due to size

Question 13

___ agonists are used to treat lactotrophs adenomas and is the first line of treatment

Answer 13

dopamine

Question 14

Thyrotroph treatments include

Answer 14

octreotide and somatostatin analogs

Question 15

Gonadotrophs present with ___ symptoms not any __ changes

Answer 15

neurological; hormonal