Pancreas and Islet Transplantation Flashcards
Severe ___ and __ are the most concerning patients
hypoglycemia; unawareness
Leading cause of death in T1D under 30
severe hypoglycemia
Normally beta cell release of __ and intake __ levels mirror each other
insulin; glucose
Normally, insulin inhibits __, but after blood glucose drops below ___ mg/ml __ becomes activated
glucagon; 70; glucagon
Why do you lose secondary sympathoadrenal response to hypoglycemia overtime?
Hypoglycemia associated autonomic failure
____ inhibitors needed for pancreas transplants have significant __ so require patients to either transplant or have a healthy __-
calcineurin; nephrotoxicity; kidney
Despite the technical difficulties what is the result of pancreas transplant?
Restoration of glucose homeostasis
After transplant, insulin sensitivity returns when ___ is dosed at physiologic levels
prednisone
_ is a marker for endogenous insulin release
C-peptide
Pancreas transplant rescues ___ function, __ response, and endogenous ___ production
islet; sympathoadrenal; glucose from the liver
1/10 grafts of pancreas grafts fail immediately due to
thrombosis
The __ serves as a sentinel for immune rejection of the pancreas
kidney
___ transplant helps improve __ transplant survival
pancreas; kidney
Kidney plus pancreas transplant helps protect against and pancreas transplant alone can help __ this
diabetic nephropathy; reverse
Pancreas alone transplant has a higher rate of __ than kidney plus pancreas transplant because of this virus
post transplant lymphoproliferative disorder; EBV
