Pituitary Physiology Flashcards
The failure of ___ of the pituitary to close during development may cause tumors
Rathke’s Pouch
What are the two activating TFs of the pituitary gland
Prop-1, Pit-1
TSH, LH, and FSH are ___ hormones and share the same _ subunit
glycoprotein; alpha
ACTH comes from the large molecule __
POMC
Both __ and __ can activate the prolactin receptor
GH; prolactin
GH stimulates secretion of __ which is responsible for ___
IGF-1; anabolic growth
TSH stimulates
thyroid hormone release
ACTH stimulates
adrenal cortex steroid release
Loss of end organ feedback results in ___ of the pituitary
hypertrophy
Circadian rhythms occur __ and ultradian rhythms are ___ style
daily; burst
ACTH stimulates __ production
cortisol
2 extra adrenal functions of ACTH
stimulate lipolysis and increase skin pigmentation
ACTH production has a ___ pattern and peaks before __
diurnal; awakening
__ inhibits ACTH release and ___ stimulates it
cortisol; CRH
GH stimulated by ___, inhibited by
GHRH, IGF-1, GH
Non-hormonal stimulators of GnRH
Hypoglycemia, protein, exercise
__ inhibits GnRH action as well as __ and __ in pituitary
somatostatin; TSH; PRL
__ is used to measure GH effect on the tissue
IGF-1
NT inhibitor of prolactin
Dopamine
Prolactin is not a closed loop- exogenous stimulators include
breast stimulation, stress, estrogen, sleep
Prolactin negatively stimulates __ and __ via __
FSH/LH; hypothalamus
__ from the hypothalamus stimulates TSH and can co-stimulate ___
TRH; prolactin
T3 decreases ___ receptors on the ___ so __ decreases
TRH; anterior pituitary; TSH
The only hypothalamus input that is inhibitory is on
prolactin via dopamine
Feedback from hormones on axis is negative except for __ during __
estrogen during ovulation
