Thyroid Pathology Flashcards
What is an oncocytic or a Hurthle cell?
Metaplastic follicular cell cell in benign or malignant lesions
___ are finger like projections into follicular cells where metaplastic cells surround a vessel and connective tissue
Papillary Formation
Diffuse Thyroid enlargement is usually _____, caused by these two things
benign, Hashimoto’s thyroiditis or Graves Disease
Graves disease on gross
Color
Increased ___
Decreased ___
red-brown, vascularity, colloid
Hallmark of Graves disease has ____
papillary hyperplasia
Graves disease Lymphocytic infiltration takes place in the ___ while hashimoto’s has lymphocytic infiltration where
stroma; everywhere
Hashimoto’s thyroiditis has ___ of the follicular cells, and becomes ___
atrophy; fibrous
Two hallmark features of Hashimoto’s thyroiditis
Cell seen in this
Lymphocytic infiltration and metaplasia (cells look pink)
Oncocytic cells
Non-toxic nodular goiter has increased __ and is hyperplasia due to less __ and more ___
Color
colloid; T3/T4; TSH
Amber
Non-toxic nodular goiters grossly have ___ (feature) due to the increased colloid
cysts
Non-toxic nodular goiters are very __ (style)
heterogenous
Non-toxic nodular goiters can also have ____ ___ (thyroid feature)
papillary formation
C-cell embryonic origin
neural crest
Follicular adenoma looks like a classic benign lesion grossly and on histo- describe 5 features (2 positive, 3 lacking)
well circumscribed, encapsulated, no invasion, hemorrhage, necrosis
Most well known etiological factor for thyroid carcinoma
Radiation
