Parathyroid and Calcium Flashcards
PTH causes bone
resorption
PTH effect on Ca andVit D n the kidney
Reabsorbs Ca and adds second hydroxy group to D
Net total effect of PTH
increases serum Ca levels
Most common cause of Parathyroid hypersecretion of PTH
solitary adenoma
Vit D effect on Gut Ca
increases gut’s absorption of calcium and phosphate
Net effect of PTH on phosphate
Loss of phosphate because you piss it all out
Primary hyperparathyroidism clinical findings
Bones, Groans (pancreatitis), Stones (kidney, stomach ulcers) , Psychic moans
Previous severe bone disease found with high PTH levels
osteitis fibrosa cystica
Today high PTH people only present with
elevated serum Ca
Primary hyperparathyroidism mostly affects ___ bone
cortical
Symptomatic patients with these two symptoms are candidates for Primary hyperparathyroidism surgery
fractures, kidney stones
Asymptomatic patients younger than __, with severe ___, with reduced ____ clearance, and low __ __
50, hypercalcemia, creatinine clearance, bone mass
Secondary hyperparathyroidism is caused by the parathyroid glands compensating for
hypocalcemia
Secondary hyperparathyroidism causes
renal insufficiency, calcium malabsorption, Vit D deficecny
Tertiary hyperparathyroidism comes after prolonged __ and one of the glands goes rouge
Secondary hyperparathyroidism
Secondary vs. Tertiary- Calcium and PTH levels
Secondary - Low Ca, High PTH
Tertiary- High Ca, High PTH
Familial Hypocalciuric Hypercalcemia is an inactivation mutation of what receptor?
The calcium sensing receptor
Lab findings for FHH
High Serum Ca, Normal/Slight high PTH, LOW URINE CALCIUM
FHH outcomes
Benign, no surgery history
Activating the calcium sensing receptors is done by high __ levels and results in what
calcium, bone formation, decreased bone resorption
Most common cause of Hypoparathyroidism
post surgical
Most concerning symptom of Hypoparathyroidism
cardiac arrhythmia
Other symptoms of Hypoparathyroidism
Tingling of fingers/toes, tetany of facial nerve or carpal spasm
What is the goal of serum calcium level in a Hypoparathyroidism patient
low normal so you don’t give em kidney stones
Vitamin D toxicity takes ___ amount and has these symptoms
a fuck ton; nausea, altered mental status
Vitamin D deficiency etiology
liver issues, kidney issues, too little intake, too little sun
Vitamin D deficiency results in
secondary hyperparathyroidism
Vitamin D deficiency causes __ bone disease in kids- common symptom
rickets, bowing of the legs
Vitamin D is responsible for bone
mineralization
