Thrombolytic Drugs

Question 1

Mechanism of action of Streptokinase

Answer 1

Binds plasminogen forming a complex that activates plasminogen to plasmin

Question 2

ADRs of Streptokinase

Answer 2

GI bleeding, Cerebral haemorrage, Produces anti-bodies

Question 3

DDIs of streptokinase

Answer 3

Bleeding with anti-coagulants

Question 4

Examples of exogenous plasminogen activators

Answer 4

Alteplase, Reteplase

Question 5

Mechanism of action of exogenous plasminogen activators

Answer 5

Activates plasminogen to plasmin

Question 6

ADRs of exogenous plasminogen activators

Answer 6

GI bleeding, Cerebral haemorrhage

Question 7

DDIs of exogenous plasminogen activators

Answer 7

Bleeding with anti-coagulants

Question 8

Risk factors for bleeding with thrombolytic drugs

Answer 8

Female, Hypertension, Cerebrovascular disease

Question 9

Contraindications for thrombolytic drug use

Answer 9

History of cerebral haemorrhage, GI trauma, or head trauma, Hypertension, Liver disease, Peptic ulcers, Bleeding disorders, or are pregnant

Question 10

Treatment for overdose of streptokinase

Answer 10

Tranexamic acid