Lipid Lowering Drugs

Question 1

Examples of statins

Answer 1

Simvostatin, Atorvastatin

Question 2

Mechanism of action of statins

Answer 2

Inhibit HMG~CoA reductase in the liver, Cause reduced cholesterol synthesis, Increases LDL receptors on liver

Question 3

ADRs of statins

Answer 3

Myopathy, Rhambdomyolysis, Elevated hepatic enzymes

Question 4

Approx Vd of statins

Answer 4

250 - 400L

Question 5

Half-life of simvostatin

Answer 5

4hrs

Question 6

Half-life of atorvastatin

Answer 6

20hrs

Question 7

DDIs of statins

Answer 7

Myopathy with fibrates, Subject to inducers and inhibitors

Question 8

Monitoring with statins

Answer 8

LFTs

Question 9

Examples of fibrates

Answer 9

Bezofibrate, Ciprofibrate

Question 10

Mechanism of action of fibrates

Answer 10

Activate PPAR alpha receptors, Causes lipid uptake and lipoysis

Question 11

ADRs of fibrates

Answer 11

GI upset, Myositis, Gall stones

Question 12

DDIs of fibrates

Answer 12

Increased risk of myopathy with statins

Question 13

Example of cholesterol uptake inhibitors

Answer 13

Ezetimibe

Question 14

Mechanism of action of cholesterol uptake inhibitors

Answer 14

Block cholesterol transport proteins in the intestines reducing uptake, Increases LDL receptors on liver

Question 15

ADRs of cholesterol uptake inhibitors

Answer 15

Headaches, Abdo pain, Diarrhoea