Anti-emetic Drugs

Question 1

Example of dopamine antagonists (Anti-emetics)

Answer 1

Domperidone

Question 2

Mechanism of action of dopamine antagonists (Anti-emetics)

Answer 2

Reduce signalling from the posterema to medullary centre

Question 3

ADRs of dopamine antagonists (Anti-emetics)

Answer 3

Hyperprolactinaemia

Question 4

Example of 5HT antagonists (Anti-emetics)

Answer 4

Ondansteron

Question 5

Mechanism of action of 5HT antagonists (Anti-emetics)

Answer 5

Reduce signalling from medullary centre to the stomach

Question 6

ADRs of 5HT antagonists (Anti-emetics)

Answer 6

Headaches, Constipation, Flushing

Question 7

Example of anti-muscarinics (Anti-emetics)

Answer 7

Hyoscine

Question 8

Mechanism of action of anti-muscarinics (Anti-emetics)

Answer 8

Reduce signalling to and from the medullary centres

Question 9

ADRs of anti-muscarinics (Anti-emetics)

Answer 9

Bradycardia, Dry mouth, Blurred vision, Constipation, Difficulty urinating

Question 10

Mechanism of action of Metaclopramide

Answer 10

Antagonise dopamine, 5HT, and ACh

Question 11

ADRs of Metaclopramide

Answer 11

Extrapyramidal signs, Glactorrhoea

Question 12

Example of histamine antagonists (Anti-emetics)

Answer 12

Cyclizine

Question 13

Mechanism of action of histamine antagonists (Anti-emetics)

Answer 13

Reduce signalling from medullary centre to the stomach

Question 14

ADRs of histamine antagonists (Anti-emetics)

Answer 14

Long QT