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Pharmacology > Antidepressant Drugs > Flashcards

Antidepressant Drugs Flashcards

1
Q

Examples of SSRIs

A

Fluoxetine, Citalopram

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2
Q

Mechanism of action of SSRIs

A

Inhibit 5HT reuptake pump, remains in the synaptic cleft

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3
Q

ADRs of SSRIs

A

Nausea, Anorexia, Diarrhoea, Mania, Suicidal intentions, Extrapyramidal signs

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4
Q

Example of Tricyclic antidepressants

A

Amityptiline

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5
Q

Mechanism of action of Tricyclic antidepressants

A

Inhibit noradrenaline reuptake, remains in the synaptic cleft

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6
Q

ADRs of Tricyclic antidepressants

A

Sedation, Constipation, Reduced contractility, Postural hypotension, Tachycardia, Lowers seizure threshold, Reduced glandular secretion

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7
Q

Example of seretonin noradrenaline reuptake inhibitors

A

Venlafaxine

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8
Q

Mechanism of action of seretonin noradrenaline reuptake inhibitors

A

Inhibit 5HT and noradrenaline reuptake, remain in the synaptic cleft

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9
Q

ADRs of seretonin noradrenaline reuptake inhibitors

A

Sleep disturbances, Hypertension, Dry mouth, Hyponatraemia

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10
Q

Mechanism of action of monoamine oxidase inhibitors

A

Prevent MAO from breaking down 5HT and noradrenaline

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11
Q

Example of Typical antipsychotic

A

Haloperidol

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12
Q

Mechanism of action of Typical antipsychotics

A

Dopamine antagonism

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13
Q

ADRs of Typical antipsychotics

A

Extrapyramidal signs, Hyperprolactinaemia, Infertility, Sexual dysfunction, Tardive dyskinesia, Hyperthermia, Postural hypotension, Weight gain, Pigmentation, Long QT

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14
Q

Example of Atypical antipsychotics

A

Risperidone

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15
Q

Mechanism of action of Atypical antipsychotics

A

Antagonise dopamine and 5HT

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16
Q

ADRs of Atypical antipsychotics

A

Weight gain, Sedation

17
Q

Mechanism of action of Lithium

A

Compete with Mg and Ca for transport or increase 5HT

18
Q

ADRs of Lithium

A

Memory problems, Polyuria, Polydipsia, Tremor, Drowsiness, Weight gain, Reduced renal function, Reduced thyroid function

19
Q

S+S of Lithium overdose

A

Vomiting, Diarrhoea, Tremor, Dysarthia, Cognitive impairment, Agitiation

Pharmacology (24 decks)

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