Laxative Drugs

Question 1

Example of bulk forming laxative

Answer 1

Vegetable fibre

Question 2

Mechanism of action of bulk forming laxatives

Answer 2

Distend intestines activating intestinal reflexes

Question 3

ADRs of bulk forming laxatives

Answer 3

Flatulence, Bowel obstruction, Dehydration

Question 4

Examples of faecal softeners

Answer 4

Arachis oil, Glycerol

Question 5

Mechanism of action of faecal softeners

Answer 5

Lubricate and soften stool

Question 6

ADRs of faecal softeners

Answer 6

Dehydration

Question 7

Examples of osmotically active laxatives

Answer 7

Mg and Na salts, Lactulose, Macrogels

Question 8

Mechanism of action of Mg and Na salts

Answer 8

Osmotically active, draw water into the colon

Question 9

Mechanism of action of Lactulose

Answer 9

Forms acetic acid, osmotically active drawing water into the colon

Question 10

ADRs of osmotically active diuretics

Answer 10

Dehydration, Electrolyte imbalances

Question 11

Examples of stimulant laxatives

Answer 11

Senokot, Dulcolax

Question 12

Mechanism of action of stimulant laxatives

Answer 12

Excite enteric nervous system, Fluid and electrolytes remain in the colon

Question 13

ADRs of stimulant laxatives

Answer 13

Hypokalaemia, Colonic atonia, Dehydration