Antibiotic Drugs Flashcards
Targets of mechanisms of action of antibiotics
DNA synthesis, Protein synthesis, Cell wall synthesis
Antibiotics that target DNA synthesis
Quinolones, Folic acid inhibitors
Antibiotics that target protein synthesis
Aminoglycosides, Macrolides, Tetracyclines
Antibiotics that target cell wall synthesis
Beta-lactams, Glycopeptides
Antibiotics that are concentration dependant
Quinolones, Aminoglycosides
Antibiotics that are time dependant
Macrolides, Beta-lactams, Glycopeptides
ADRs of Quinolones
Nausea, Vomiting, Headache, Insomnia, C. Diff, Long QT
ADRs of Folic acid inhibitors
Hyperkalaemia
ADRs of Aminoglycosides
Nephrotoxicity, Ototoxicity
ADRs of Macrolides
Nausea, Vomiting
ADRs of Tetracyclines
Nausea, Vomiting, Teeth staining, Tinnitis, Reduced foetal bone growth
ADRs of Penicillins
Allergy, Diarrhoea, Nausea, Neurotoxicity, Hives, Erythema, Colitis, Angioedema
ADRs of Cephalosporins
C. Diff, Vomiting, Headaches, Allergy
ADRs of Glycopeptides
Nephrotoxicity, Ototoxicity, Bone marrow damage
Mechanisms of antibiotic resistance
Inactivate antibiotics, Alter target site, Alter physiological pathways, Expel drug from cell, Reduce influx into cell
