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Pharmacology > Immunosuppressant Drugs > Flashcards

Immunosuppressant Drugs Flashcards

1
Q

Examples of corticosteroids

A

Prednisone, Hydrocortisone

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2
Q

Mechanism of action of corticosteroids (Immunosuppressants)

A

Reduce production of interleukin 1 and 6, inhibit the action of T cells

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3
Q

ADRs of corticosteroids

A

Weight gain, Glucose intolerance, Insomnia, Hypertension, Psychosis, Gastritis, Pancreatitis, Osteoporosis

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4
Q

Monitoring of corticosteroids

A

Monitor inflammatory markers

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5
Q

Mechanism of action of Azathioprine

A

Forms 6-MP which inhibit purine synthesis, reduces DNA synthesis, reduces lymphocyte number

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6
Q

ADRs of Azathioprine

A

Myelosuppression, Lymphoma, Infection, Hepatitis

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7
Q

Monitoring of Azathioprine treatment

A

LFTs and FBCs

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8
Q

Test before Azathioprine treatment

A

Test for TPMT levels

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9
Q

Mechanism of action of methotrexate (Immunosuppressant)

A

Increased adenosine levels reducing T cell activity

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10
Q

ADRs of methotrexate

A

Mucositis, Myelosuppression, Hepatitis, Cirrhosis, Infection, Pneumonitis, Teratogenesis

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11
Q

Monitoring during methotrexate treatment

A

FBCs, LFTs, U+Es, CXR

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12
Q

Mechanism of action of Sulphasalazine

A

Salicylate in colon reducing cytokines, Sulphpyridine in circulation reduces interleukin 2 production in T cells

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13
Q

ADRs of Sulphsalazine

A

Myelosuppression, Hepatitis, Nausea, Vomiting, Abdo pain

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14
Q

Mechanism of action of Cyclophosphamide

A

Metabolites act as alkylating agents inhibiting DNA synthesis, reduces lymphocyte number

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15
Q

ADRs of Cyclophosphamide

A

Bladder cancer, Leukaemia, Infertility

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16
Q

DDIs of Cyclophosphamide

A

Effected by inducers and inhibitors

17
Q

Mechanism of action of Mycophenolate Mofetil

A

Inhibits guanine synthesis, reducing lymphocyte number

18
Q

ADRs of Mycophenolate Mofetil

A

Nausea, Vomiting, Leukopenia, Neutropenia, Myelosuppression, Infection

19
Q

Examples of Calcineurin inhibitors

A

Ciclosporin, Tacrolimus

20
Q

Mechanism of action of Calcineurin inhibitors

A

Inhibit calcineurin preventing the transcription of interleukin 2

21
Q

ADRs of Calcineurin inhibitors

A

Nephrotoxicity, Hypertension

22
Q

DDIs of Calcineurin inhibitors

A

Effected by inducers and inhibitors

23
Q

Monitoring of Calcineurin inhibitor treatment

A

BP, eGFR

Pharmacology (24 decks)

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