Non-steroidal Anti-inflammatory Drugs

Question 1

Examples of NSAIDs

Answer 1

Ibuprofen, Naproxen

Question 2

Mechanism of action of NSAIDs

Answer 2

Inhibit COX 2 preventing the conversion of arachidonic acid to prostaglandins

Question 3

Action of EP1 receptors

Answer 3

Cause hyperalgesia

Question 4

Action of EP2 receptors

Answer 4

Cause vasodilation

Question 5

Action of EP3 receptors

Answer 5

Cause fever

Question 6

ADRs of NSAIDs

Answer 6

Bronchial asthma, Peptic disease, Reduced GFR, Reduced clotting, Reye’s syndrome, Stevens Johnson syndrome

Question 7

Describe Reye’s syndrome

Answer 7

Rash, Encephalopaty, and fatty liver caused by giving minors aspirin

Question 8

Describe Stevens Johnson syndrome

Answer 8

Hepatic damage, and inflammation of mucosal membranes

Question 9

Describe how NSAIDs are made selective for COX 2

Answer 9

Made bigger, COX 1 has a narrower active site

Question 10

DDIs of NSAIDs

Answer 10

Displacement of plasma protein bound drugs, Bleeding with anti-coagulants

Question 11

Mechanism of action of Paracetamol

Answer 11

Inhibition of COX enzymes in the CNS

Question 12

ADRs of Paracetamol

Answer 12

Hepatic damage, Stevens Johnson syndrome