Anaesthetic Drugs

Question 1

Examples of Fluranes

Answer 1

Isoflurane, Halothane

Question 2

Mechanism of action of Fluranes

Answer 2

Bind allosterically to GABA receptors, increasing sensitivity, increasing Cl conductance hyperpolarising the membrane

Question 3

ADRs of Fluranes

Answer 3

Resp depression, Cognitive dysfunction

Question 4

Mechanism of action of Nitrous oxide

Answer 4

Inhibit NMDA receptors reducing Ca influx

Question 5

Mechanism of action of Propofol

Answer 5

Bind allosterically to GABA receptors increasing sensitivity, increasing Cl influx hyperpolarising the membrane

Question 6

ADRs of Propofol

Answer 6

Resp depression, Hypotension

Question 7

Define MAC

Answer 7

Conc in lungs at which 50% of population won’t respond to surgical stimuli

Question 8

Factors increasing MAC

Answer 8

Youth, High temp, Pregnancy, Alcoholism, Stimulants

Question 9

Factors decreasing MAC

Answer 9

Opioids, Anaesthetics, Low temp

Question 10

Guedal signs stage 1

Answer 10

Analgised but conscious

Question 11

Guedal signs stage 2

Answer 11

Hypertonic, Increased eye movements

Question 12

Guedal signs stage 3

Answer 12

Muscles relaxed, Reduced resp rate

Question 13

Guedal signs stage 4

Answer 13

Resp depression

Question 14

Phases of anaesthesia

Answer 14

Reveiw, Peri-surgical monitoring, Induction, Maintenance, Recovery

Question 15

Actions in the review phase of anaesthesia

Answer 15

Review patient history, Assess airways

Question 16

Actions in the peri-surgical monitoring phase of anaesthesia

Answer 16

Measure physiological parameters

Question 17

Actions in the induction phase of anaesthesia

Answer 17

Give IV agent, inhaled agents started

Question 18

Actions in the maintenance phase of anaesthesia

Answer 18

Maintain unconsciousness

Question 19

Actions in the recovery phase of anaesthesia

Answer 19

Inhaled agents stopped, antidotes given