Diuretics

Question 1

Examples of loop diuretics

Answer 1

Furosemide, Bumetanide

Question 2

Mechanism of action of loop diuretics

Answer 2

Inhibit Na/K/2Cl co-transporter in the TAL

Question 3

ADRs of loop diuretics

Answer 3

Hypokalaemia, Hypovolaemia, Anaphylaxis, Myalgia (Bumetanide), Ototoxicity (Furosemide)

Question 4

DDIs of loop diuretics

Answer 4

Hypokalaemia with steroids

Question 5

Examples of thiazide diuretics

Answer 5

Bumetanide

Question 6

Mechanism of action of thiazide diuretics

Answer 6

Inhibit Na/Cl co-transporter in the DCT

Question 7

ADRs of thiazide diuretics

Answer 7

Gout, Hypokalaemia, Erectile dysfunction, Hypovolaemia

Question 8

DDIs of thiazide diuretics

Answer 8

Hypokalaemia with steroids

Question 9

Example of K sparing diuretic

Answer 9

Amiloride

Question 10

Mechanism of action of K sparing diuretics

Answer 10

Inhibit ENaC in the DCT and CT

Question 11

ADRs of K sparing diuretics

Answer 11

Hyperkalaemia, Hypovolaemia

Question 12

DDIs of K sparing diuretics

Answer 12

Hyperkalaemia with ACE-I

Question 13

Example of aldosterone antagonist

Answer 13

Spirononlactone

Question 14

Mechanism of aldosterone antagonists

Answer 14

Reduce the number of ENaC

Question 15

ADRs of aldosterone antagonists

Answer 15

Hyperkalaemia, Hypovolaemia, Painful gynaecomastia

Question 16

DDIs of aldosterone antagonists

Answer 16

Hyperkalaemia with ACE-I