Anti-arrhythmic Drugs Flashcards
Examples of Class I anti-arrhythmic Drugs
Lidocaine, Flecainide
Mechanism of action of Class I anti-arrhythmic Drugs
Block Na channels, Slow conductance in phase 0 of cardiac action potential
ADRs of Class I anti-arrhythmic Drugs
Hypotension, Long QT, Dizziness, Confusion, Insomnia, Seizures, GI upset
Indications for Class I anti-arrhythmic Drug use
Rhythm control -AF
Examples of Class II anti-arrhythmic Drugs
Atenolol, Bisoprolol
Mechanism of action of Class II anti-arrhythmic Drugs
Beta blockers, Reduce SNS input slowing conduction through the AV node
ADRs of Class II anti-arrhythmic Drugs
Bronchospasm, Hypotension, Reduced contractility
Indication for Class II anti-arrhythmic Drug use
Rate control -SVT, Sinus tachycardia
Examples of Class III anti-arrhythmic Drugs
Amiodarone, Sotalol
Mechanism of action of Class III anti-arrhythmic Drugs
Block K channels preventing repolarisation increasing the refractory period
ADRs of Amiodarone
Arrhythmia, Pulmonary fibrosis, Photosensitivity, Thyroid disease, Liver damage
ADRs of Sotalol
Arrhythmia, Fatigue, Insomnia
Indications for Class III anti-arrhythmic Drug use
Rhythm control - most arrhythmias
Example of Class IV anti-arrhythmic Drugs
Verapamil
Mechanism of action of Class IV anti-arrhythmic Drugs
Block Ca channels, reducing influx of Ca in the cardiac and pacemaker potentials, slowing conductance through the AV node
ADRs of Verapamil
Hypotension, GI upset
Indications for Class IV anti-arrhythmic Drug use
Rate control - SVT
Mechanism of action of Adenosine
Activate alpha 1 receptors opening K channels, causes hyperpolarisation increasing the refractory period, slows conductance through the AV node
ADRs of Adenosine
Nausea, Lightheadedness, Sense of impending doom
Indications for Adenosine use
Acute management of SVT
