The human microbe L6 Flashcards
what defines a healthy state
a wide range of microbes
microbe=
the combined genetic material of the microorganism in a particular environment
name 6 things that may affect the microbe
diet host genetics immune response microbial co-adaptation age lifestyle
5 things the microbe of your gut affects
1.development of immune system 2,prevent colonisation with pathogens 3.produce beneficial nutrients/ compounds 4.destroying toxins 5.metabolism
when may commensal species cause infection (3)
- Spread into sterile parts of the body
- Expand in population size
- normal balance is disturbed
benefit of normal flora
competes with pathogen
describe C diff in 3 facts
Gr+
Anaerobic
spore former
C diff=
clostridium difficile
what increases the amount of C diff in the gut
antibiotic selective pressure
what can C diff cause
antibiotic associated diarrhoea
what would normally control C diff sporulation
microbiome metabolites
what causes C diff to grow (body produces)
Primary Bile salts
what inhibits vegetative growth of C.diff
Secondary bile salts
would C.diff pass Koch’s postulates
NO
dysbiosis=
imbalance of the normal gut microbial composition
