Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

ACLAM Boards > The Guide > Flashcards

The Guide Flashcards

1
Q

According to The Guide and the AWA/AWR, whose responsibility is it to ensure that all scientists, research technicians animal technicians and other personnel involved in animal care, tx and use are qualified to perform their duties?
A) AV
B) IACUC
C) PI
D) Research facility/institution

A

D

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

The production of monoclonal antibodies in mouse cell culture as opposed to harvesting them in a mouse ascites fluid is an example of which of the following concepts?
A) Refinement
B) Relative replacement
C) Reduction
D) Absolute replacement
E) Responsibility

A

B

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

According to The Guide, responsibility for review and investigation of animal welfare concerns in the US rests with the____
A) AV
B) IO and IACUC
C) IACUC chair
D) CEO or vice president of research

A

B

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

The Guide recommends that rooms housing albino animals have which of the following light levels?
A) 30 lux at 1 ft above the floor
B) 30 lux at 3.3 ft above the floor
C) 325 lux at 1 ft above the floor
D) 325 lux at 3.3 ft above the floor

A

D

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Which type of diet has been assayed for contaminants and is commercially available for use in select studies, such as preclinical toxicology, conducted in compliance with FDA GLP standards?
A) Natural ingredient diet
B) Purified diet
C) Certified diet
D) Chemically defined diet

A

C

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

According to The Guide, what chemicals MUST be removed from water used in aquatic systems before housing fish and amphibians?
A) Ammonia and nitrite
B) Calcium carbonate and magnesium
C) Chlorine and chloramines
D) Nitrite and nitrate

A

C

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Which of the following statements is most consistent regarding laboratory animal allergies?
A) Urine proteins are the main source of allergenic proteins in mice and rats
B) Saliva proteins are the main source of allergenic proteins in mice and rats
C) Personal protective equipment should be the major protective mechanism for allergies
D) Laboratory animal allergies are not a concern of the institutional health and safety program

A

A

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Which of the following is the recommended light intensity range at the cage level to prevent phototoxic retinopathy?
A) 30-130 lux
B) 30-300 lux
C) 60-180 lux
D) 130-325 lux

A

D (p. 48)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

According to The Guide, adult zebrafish in typical biomedical research settings in the US are generally housed how many fish per liter of water?
A) 3
B) 4
C) 5
D) 6
E) 10

A

C (p. 83)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

According to The Guide, who is responsible for determining that personnel performing surgical procedures are appropriately qualified and trained?
A) AV
B) IACUC
C) PI
D) IACUC and AV
E) PI and IACUC

A

D (p. 115-116)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Regarding the management and housing of aquatic animals, which of the following is NOT a category of life support system according to The Guide?
A) Static system
B) Aerated system
C) Flow-through system
D) Recirculating system

A

B (p. 79)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

According to the most recent version of The Guide, what is the recommended minimum floor area for a female rat with a litter?
A) 51 in^2
B) 70 in^2
C) 101 in^2
D) 124 in^2
E) 150 in^2

A

D (p. 57)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

According to The Guide, what is the recommended dry bulb temperature for poultry?
A) 16-22C (61-72F)
B) 16-27C (61-81F)
C) 18-29C (64-84F)
D) 20-26C (68-79F)

A

B (p. 44)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

According to The Guide, what is the recommended dry bulb temperature for gerbils?
A) 16-22C (61-72F)
B) 16-27C (61-81F)
C) 18-29C (64-84F)
D) 20-26C (68-79F)

A

D (p. 44)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

According to The Guide, what is the recommended dry bulb temperature for rabbits?
A) 16-22C (61-72F)
B) 16-27C (61-81F)
C) 18-29C (64-84F)
D) 20-26C (68-79F)

A

A (p. 44)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Which of the following is TRUE regarding the thermoneutral zone of an animal?
A) Ambient temperature must fall within the TNZ of the species housed in order to be within regulatory compliance
B) Temperatures outside of the TNZ result in physiologic and behavioral adjustments to ensure homeostasis
C) Temperatures below the TNZ result in reduced basal metabolic rate due to reduced energy expenditure
D) TNZ of mice includes the temperature range 20-26C
E) An animal’s basal metabolism is greatest within (rather than outside of) its TNZ due to promotion of natural behaviors such as nest building and huddling

A

B (p. 43)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Saimiri sciureus may be latently infected with herpesvirus saimiri, which could be transmitted to and cause fatal epizootic disease in ___
A) Aotus trivirgatus
B) Macaca mulatta
C) Macaca arctoides
D) Papio anubis

A

A (p. 112)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Which of the following statements is FALSE regarding training/education as described in The Guide or AWA?
A) Institutions are responsible for providing adequate training of IACUC committee members
B) The AV and IACUC are responsible for determining that personnel performing sx are appropriately qualified and trained in the procedures
C) Vets providing health care for lab animals must be graduates of US vet schools
D) All research personnel should receive institutional training in animal care and use legislation
E) Training must be pertinent to the species and studies in an institution

A

C (p. 15-16, 110)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

According to The Guide, solid-bottomed caging, bottles and sipper tubes should be sanitized at least how often?
A) At least once a day
B) At least once a week
C) At least once every 2 weeks
D) At least once a month

A

B (p. 70)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

According to The Guide, what is the minimum recommended floor space for a 3 kg cat?
A) 4 ft^2
B) 1.5 ft^2
C) 5 ft^2
D) 3 ft^2
E) 2 ft^2

A

D (p. 59)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

What is the recommended storage temperature for natural ingredient feed?
A) 4C (40F)
B) 15C (60F)
C) 21C (70F)
D) 27C (80F)

A

C (p.66); purified and chemically defined diets at 4C

22
Q

According to The Guide, what type of monitoring should be done to ensure that an animal’s nutritional needs are met when food or fluids are regulated or restricted as part of a study?
A) BW recorded daily
B) BW recorded at least weekly
C) Fecal and urine output daily
D) Fluid consumption at least weekly
E) Food consumption at least weekly

A

B (p. 31)

23
Q

Because most magnetic resonance (MR) scanners require the use of cryogens, rooms with MR scanners MUST be equipped with which of the following?
A) CO2 sensors
B) Fire extinguishers
C) Nitrogen sensors
D) Oxygen sensors
E) Superconducting gloves

A

D (p. 146-147)

24
Q

According to The Guide, what is the minimum height requirement for a primary enclosure housing a rabbit?
A) 12 in
B) 14 in
C) 16 in
D) 18 in
E) 20 in

A

C (p. 59)

25
Q

According to The Guide, which of the following statements applies to animals maintained in outdoor runs, pens or other large enclosures?
A) Should have protection from extremes in temperature or other harsh weather conditions and adequate opportunities for retreat
B) Must have protection from extremes in temperature or other harsh weather conditions and adequate opportunities for retreat
C) Do not require protection from extremes in temperature or other harsh weather conditions and adequate opportunities for retreat
D) Sometimes need protection from extremes in temperature or other harsh weather conditions and adequate opportunities for retreat

A

B (p. 54)

26
Q

Which of the following best describes the purpose of a biofilter?
A) Remove algae
B) Limit microorganisms
C) Limit ammonia and nitrite accumulation
D) Remove excessive dissolved gases
E) Remove dissolved chemicals

A

C (p. 79)

27
Q

According to The Guide and AWA/R, dog runs should be sanitized at least how often?

A

Every 2 weeks (p. 70-72)

28
Q

What is the minimum height requirement for a primary enclosure housing a cat in a research facility?
A) 16 in
B) 24 in
C) 32 in
D) 46 in

A

B (p. 59)

29
Q

According to The Guide, what is the recommended dry bulb temperature range for mice and rats?

A

20-26C (68-79F)

30
Q

Which of the following animal ID techniques requires the use of anesthesia in mice greater than 2 weeks of age?
A) Ear tags
B) Ear notch
C) Toe clipping
D) Tattoo
E) Microchipping

A

C (p. 75)

31
Q

According to The Guide, what is the minimum floor space required for an individually housed 5 kg NZW rabbit?

A

4 ft^2 (p. 59)

32
Q

The presence of which of the following agents leads to increased algal growth in aquatic systems?
A) Nitrogen and phosphorus
B) Nitrogen and oxygen
C) Nitrogen and carbon dioxide
D) Phosphorus and carbon dioxide

A

A (p. 86)

33
Q

According to The Guide, toe clipping may be the preferred ID method for neonatal mice up to how many days of age?

A

7 (p. 75)

34
Q

What is a purified diet?

A

Each ingredient contains a single nutrient or nutrient class; less nutrient concentration variability and risk of contamination lower (p. 65)

35
Q

What is a certified diet?

A

Have been assayed for contaminants and are available commercially for use in select studies, such as preclinical tox conducted in compliance with FDA GLP (p. 65)

36
Q

What is a chemically defined diet?

A

Contain the most elemental ingredients available (amino acids, specific sugars)
(p. 65)

37
Q

Which of the following is true regarding a properly designed and functioning HVAC system?
A) Areas for quarantine, housing and use of animals exposed to hazardous materials and housing of NHPs should be kept under relative positive pressure
B) HVAC systems should be capable of adjustments to ideally maintain dry bulb temps of +/- 2C
C) Valves controlling reheat coils should fail in the closed position
D) Relative humidity should generally be maintained within range of 30-60%
E) Ideally relative humidity should be maintained within +/- 5% of set point

A

C is true
A- Negative pressure
B- +/- 1C (+/- 2F)
D- 30-70%
E- +/- 10% of set point

38
Q

According to The Guide, what is the height requirement for a cage containing two 300g guinea pigs?

A

7 in (p. 57)

39
Q

According to The Guide, what is the minimum space recommended for housing a 95 kg sow?

A

24 ft^2 (p. 62)

40
Q

According to The Guide, whose responsibility is it to ensure that IACUC members are provided training opportunities to understand their work and role?

A

The institution (p. 17)

41
Q

What does each filter type remove from an aquatic system?
1) Biofilter
2) Protein skimmers (foam fractionators) and particulate filters
3) Carbon filters
4) UV or ozone

A

1) Ammonia –> Nitrite and nitrate
2) undissolved and dissolved proteins and particulate matter
3) Dissolved chemicals
4) Pathogens
(p. 79)

42
Q

According to The Guide, the IACUC should conduct program reviews and facility inspections at what minimum interval?

A

The Guide does not specify a minimum frequency (p. 25)

43
Q

According to The Guide, interinstitutional collaborations should have a formal written understanding that addresses what 3 concerns?

A

Responsibility for offsite animal care and use, animal ownership and IACUC review/oversight (p. 15)

44
Q

What is the recommended minimum diameter for most floor drains?

A

4 in/10.2 cm; 6 in/15.3 recommended in some facilities such as dog kennels and ag facilities (p. 138)

45
Q

According to The Guide, what is the recommended minimum floor area for a female mouse with a litter?

A

51 in^2 (p. 57)

46
Q

According to The Guide, what are the criteria defining a major survival surgery?

A

1) Penetrates and exposes a body cavity
2) Produced substantial impairment of physical or physiologic function
3) Involves extensive tissue dissection or transection –> Not a criteria in the AWA/R
(p. 117)

47
Q

Cedar shavings are not recommended for use as bedding material b/c they emit what kind of substances that can affect the function of what organ?

A

Aromatic hydrocarbons; liver (p. 69)

48
Q

According to The Guide, what is the recommended minimum floor area for a quail?

A

0.25 ft^2 (p. 60)

49
Q

According to The Guide, to reduce putrefaction of dead animals and wastes, refrigerated storage areas should be kept below what temperature?

A

7C (44.6F)
(p. 142)

50
Q

Unrelieved pain can lead to a painful response to normally non-painful stimuli. What term describes this condition?

A

Allodynia (p. 120)

51
Q

According to The Guide, what is the minimum temperature needed for wash and rinse water in order to achieve effective disinfection?

A

143; range of 143-180F or more (p. 71)

52
Q

Who developed The Guide?

A

The National Research Council (p. xi)

ACLAM Boards (9 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions