NHPs Flashcards
Temperature range for NHPs
64-84F
Minimum relative humidity for tamarins and marmosets
50%
Vaccines typically given to NHPs
Rabies, tetanus +/- MMR
Most common site for blood collection from NHPs
Femoral vein
Safe amount of blood to draw from an NHP
No more than 10-15% of total blood volume per 2 weeks
Maximum volume of SC administration in NHPs
5 ml/kg/site
Insertion of NG tubes in OWM vs NWM
OWM: Downward orientation of nares –> Upward insertion
NWM: Laterally flared nares –> Lateral insertion
What are vero cells and from what species do they originate?
Kidney epithelial cell line from Chlorocebus (African green)
What is MPTP used to induce?
Parkinson’s disease
What is MOG and what is it used for?
Myelin oligodendrocyte glycoprotein
Induces EAE
What is S. oedipus commonly used to study?
Cotton top tamarin
Chronic colitis and colon adenocarcinoma
What NHP species are CITES I?
S. oedipus (cotton top tamarin), Saimiri oerstedii (black crowned squirrel monkey), Macaca silenus (lion tailed macaque), Pan
What species is used to study baldness?
Stump tailed macaque (M. arctoides)
What species are used in the MPTP induced model of Parkinson’s dz?
C. jacchus (marmoset), Chlorocebus aethiops (African green), M. mulatta (Rhesus), Pig-tailed macaque (M. nemestrina)
What species are used as an EAE model? What is used to induce it?
Myelin oligodendrocyte glycoprotein (MOG)
C. jacchus (marmoset), M. mulatta (Rhesus), M. fascicularis (cyno)
What species is used to study pelvic organ prolapse?
Saimiri spp. (Squirrel monkey)
What species are used to study cardiomyopathy?
Saimiri spp. (squirrel monkey) and Sanguinus mystax (mustached tamarin)
What enteric bacterial infection also causes gingivitis?
Shigella
A macaque presents with mucohemorrhagic diarrhea. Three weeks later, he develops lameness on one limb. What is the agent?
Shigella
What species of Helicobacter is associated with colonic adenocarcinoma in macaques?
H. macacae
What agent causes fatal proliferative enteritis in juvenile rhesus?
Lawsonia intracellularis
What is the clinical manifestation of S. pneumoniae in NHPs?
Pneumonia, meningitis, rapidly progresses to death
Low morbidity, high mortality
What does Klebsiella pneumoniae cause in NHPs?
Pneumonia, meningitis, air sacculitis
Young more commonly affected
What histopathology findings are characteristic of nocardia infection?
Pyogranulomas with sulfur granules and large colonies of filamentous bacteria
What bacteria causes epistaxis in cynos, especially in dry months? How is it treated?
Moraxella catarrhalis
Long-acting penicillin
What are the differential diagnoses for cavitary lesions in the lungs?
Nocardia, TB, crypto, coccidiosis, Yersinia
What is the gold standard diagnostic for tuberculosis?
Culture
What bacterium is associated with acute gastric dilation in NHPs?
C. perfringens
What is the most common opportunistic infection of macaques with SIV?
Pneumocystis
Stain needed to visualize pneumocystis?
Silver or PAS
Where in the country is Coccidioides immitis found?
Southwest US
What are the characteristic lesions of Coccidioidmycosis?
Lesions in the lungs and vertebrae (cavitary lung lesions and/or vertebral bone lysis)
What clinical signs does HIstoplasma capsulatum cause? Dx?
Disseminated microgranulomas confined to the skin
GMS stain - See halo around organisms
What pathology findings are associated with Candidiasis?
White plaques on tongue, buccal cavity, esophagus, intestines
Which systemic mycoses is associated with bat feces?
HIstoplasmosis
Where can macacine herpesvirus 1 (herpes B) found during latent infection?
Trigeminal and lumbosacral ganglia
Inclusion bodies seen with macacine herpesvirus I infection?
Intranuclear inclusion bodies (Cowdry type A)
What clinical signs does papiine herpesvirus 2 cause in baboons?
Often asymptomatic +/- transient oral and genital lesions
Hepatocellular necrosis and pulmonary alveolitis in neonates
Baboons should be kept separate from other NHPs due to what virus?
Papiine herpesvirus 2
Why should saimiri be separated from aotus and callitrichids?
Saimirine herpesvirus 1 (SAHV1)
Asymptomatic in saimiri, but fatal in aotus and callitrichids
Clinical signs in aotus and callitrichids infected with human herpesvirus 1 or 2?
Multisystemic necrosis + encephalitis
Clinical presentation of cercopithecine herpesvirus 9
In aberrant hosts (African and Asian NHP spp) –> Vesicular dermatitis (rarely involving hands/feet) progressing to death within 48 hours
Clinical presentation of SIV positive macaques infected with macacine herpesvirus 4?
B cell lymphoma and oral hairy leukoplakia
What other virus are NHPs also infected with when they develop RFHV induced retroperitoneal fibromatosis?
Simian retrovirus 2 (SRV2)
Clinical presentation of saimiriine herpesvirus 2 and ateline herpesvirus 2,3?
None in natural host (Squirrel and spider monkeys)
Lymphoma in callitrichids and aotus
