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Animal Models Flashcards

1
Q

Homologous definition

A

Animal symptoms and causes of condition are identical to humans

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2
Q

Isomorphic definition

A

Animal symptoms are similar but the cause of the symptoms is different

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3
Q

Animal model(s) of DiGeorge Syndrome

A

-Congenital athymia
-Nude mouse and nude streaker mouse

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4
Q

Chediak-Higashi syndrome

A

-Beige mouse (Lyst^bg mutation on chromosome 13)
-Smoke blue persian cats, hereford cattle, brangus cattle, Aleutian mink, killer whales, silver fox

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5
Q

X linked agammaglobulinemia

A

XID mouse

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6
Q

NZBxNZWF1 mouse

A

Model of systemic lupus erythematosus

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7
Q

Hirschsprung’s Disease

A

-Congenital agangliosis –> Megacolon
-Piebald (Ednrb^s-l) and lethal spotting (Edn3^ls) mice and spotting lethal rat

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8
Q

Mouse models of obesity

A

ob/ob (leptin expression) and db/db (leptin receptor function)

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9
Q

Adenocarcinoma of the colon

A

-Intragastic administration of 1,2-dimethylhydrazine (DMH) to weanling Wister rats
-Azoxymethane and DSS administration to APC mutant mice

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10
Q

Mouse models of teratomas

A

129 and A/He strains

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11
Q

Diabetes insipidus

A

Brattleboro rat

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12
Q

Diabetes mellitus type I

A

Mystromys albicuadatus (white-tailed rat), BB Wister rat, NOD mouse, Cricetulus griseus (Chinese hamster)

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13
Q

Rat model of obesity

A

Zucker fa/fa rat (leptin receptor mutation)

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14
Q

Interstitial cell tumor

A

F344 rat

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15
Q

Halothane-associated hepatitis

A

Guinea pig and rat

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16
Q

Duchenne muscular dystrophy

A

Golden retriever muscular dystrophy (DMD mutation), mdx mouse

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17
Q

Limb-Girdle muscular dystrophy

A

Hereditary myopathy in labs, Boston terriers, SJL/J mice

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18
Q

Other models of muscular dystrophy

A

White Pekin ducks (Anas platyrhynhas), turkey, New Hampshire chicken, merino sheep, mink, Syrian hamster

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19
Q

Cyclic neutropenia

A

Gray collie

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20
Q

Ehlers-Danlos syndrome

A

Dogs and mink (connective tissue defect and increased skin laxity)

21
Q

Pelger-Huet Anomaly

A

Dogs and rabbits (granulocytes don’t develop normal segmentation)

22
Q

GM1, gangliosidnosis

A

German shorthair pointer, Freisian cattle

23
Q

Von Willebrand’s disease

A

GSD, mini shnauzers, golden retrievers, Scottish terriers, Dobermans, Poland China swine, chinchilla-Flemish giant rabbit (Factor 8 deficiency)

24
Q

Pyruvate kinase deficiency

A

Basenji, Beagle (congenital hemolytic anemia)

25
Q

Rabbit models of atherosclerosis

A

Watanabe heritable hyperlipidemic rabbit (LDL receptor deficiency), St. Thomas Hospital rabbit (LDL increased), KHC rabbit (like WHHL + calcification of coronary artery)

26
Q

Nephroblastoma

A

IV ENU administration to pregnant rabbit doe on day 18 of gestation

27
Q

Pig model of melanoma

A

Sinclair minipig

28
Q

Pregnancy toxemia

A

Patas monkeys (Erythrocebus patas) and guinea pigs

29
Q

Male pattern baldness

A

Stumptailed macaque (Macaca arctoides)

30
Q

Lymphocytic thyroiditis

A

-Hashimoto’s disease
-Callithrix jacchus, Buffalo rat, beagle, BB Wistar rat, obese chicken

31
Q

Leprosy (Hansen’s disease)

A

Sooty Mangabey (Cercocebus toquantus atys), armadillo

32
Q

Aural cholesteatoma

33
Q

Hep B

A

Woodchuck, Beechy ground squirrel

34
Q

Periodontitis

A

Rice rat (Oryzomys palustris)

35
Q

Stroke

A

Gerbil (incomplete circle of Willis)

36
Q

Atrial thrombosis

A

Aged Syrian hamster (usually L atrium)

37
Q

Cholelithiasis

A

Richardson ground squirrel (Urocitellus richardsonii)

38
Q

Legionnaire’s disease

A

Guinea pig

39
Q

Klinefelter’s syndrome

A

Tortoiseshell (calico) male cats

40
Q

Porphyria

A

Cats, cattle, swine

41
Q

Spina bifida

42
Q

Reye’s syndrome

A

Young ferret infected w/ influenza B, given aspirin in water and arginine free diet

43
Q

B-mannosidosis

A

Nubian goats

44
Q

Ruminant model of melanoma

A

Angora goats

45
Q

Congenital hyperbilirubinemia

A

Dubin-Johnson syndrome (conjugated bilirubin): Corriedale sheep

Gilbert syndrome (Unconjugated): Shouthdown sheep, Bolivian squirrel monkey

Gunn rat

46
Q

Wilson’s disease

A

White perch (Merone americana), Long Evans cinnamon rat, bedlington terrier, sheep

47
Q

Autoimmune disease rodent models

A

New Zealand black and New Zealand white mice

48
Q

Primary hypertension

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