Terminal Oxidation Flashcards
Sources of CoEnzymes + locations
Glycolysis (then transported to mitochondrial matrix)
PDH - cytosol
TCA - cytosol
Beta oxidation - cytosol
Terminal Oxidation - def., parts, location
Produce ATP from reducing power of NADH and FADH
Electron transport and oxidative phosphorylation
Mitochondrial inner membrane
electron transport
Electron carriers transfer electrons and protons from reduced co-enzymes to oxygen
oxidative phosphorylation
reducing power of electron transport is converted into ATP energy
Components of electron transport chain
4 complexes
CoEnzyme Q
Cytochrome c
What happens to protons in ETC?
protons removed are pumped across membrane to create electrochemical gradient that provides energy for ATP synthesis
Complex I
NADH enters system, and transfers electrons and protons to CoQ (through FMN)
Complex II , driving enzyme
FADH enters system, transfers electrons and protons, to CoEnzyme Q (prefaced by succinate/fumarate)
-succinate dehydrogenase
CoEnzyme Q
Accepts electrons. Transfer them to Complex III
Complex III
transfers electrons to cytochrome c
cytochrome c
trasnports electrons to Complex IV
Complex IV
transfers electrons to molecular oxygen
What stops/damages ETC?
Carbon Monoxide, Sodium Azide, Potassium cyanide
Poison complex 4-b/c it works with molecular oxygen, (and hemoglobin)
What stops Complex III?
Antimycin - an antibiotic
also Myxothiazol and Stigmatelin
Cyanide Poisining - antidotes (+Fxn)
Nitrites - convert hemoglobin to methemoglobin by oxidizing Fe2+ to Fe3+
Methemoglobin then competes with cytochrome a3 (fe3+) for cyanide
causes small problem in blood cell oxygenation but overall allows for ETC to continue
