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Undeleted > Antibiotics > Flashcards

Antibiotics Flashcards

0
Q

Tetracylines

A

Inhibits binding of aminoacyl-tRNA’s to mRNA-ribosome complex

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1
Q

Streptomycin

A

Prevents binding of fmet-tRNA to prokaryotic ribosomes
Interferes with initiation of protein synth
Causes misreading of codons
Mutations in proteins associated with the small subunit can confer resistance or even dependence

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2
Q

Puromycin

A

analog of aminoacyl-tRNA
Binds to A-site. Stops chain elongation
Incomplete polypeptide chains formed with puromycin located on C-terminus
Works well in BOTH eukaryotes and prokaryotes

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3
Q

Erythromycin

A

Inhibits peptidyl transferase in prokaryotes

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4
Q

Cylcoheximide

A

Inhibits pepdityle transferase in EUKARYOTES

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5
Q

Ricin

A

Toxin (castor beans) attacks rRNA by removing adenine

Inactivates rRNA

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6
Q

Nalidixic Acid

A

Antibacterial (quinolone)
Inhibits DNA replication
Inhibits DNA gyrase & topoisomerase

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7
Q

Alpha Amanitin

A

Poison

Inhibits RNA poly I and II

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