Targeting to the ER SRP

Question 1

SRP

Answer 1

Signal Recognition Particle

Question 2

What is the purpose of the SRP?

Answer 2

To target peptides the ER

Question 3

SRP function process

Answer 3

1) SRP binds to N-terminus of the polypeptide and ribosome by sitting in the A site halting translation 2) Binding help peptide to find SRP receptor on the ER 3) protein enters ER unfolded 4) signal peptidases cleave signal sequence.