Lipid Metabolism

Question 1

What is the first step of fatty acid oxidation?

Answer 1

1) Activate the fatty acids with a CoASH

Question 2

Steps of fatty acid oxidation

Answer 2

1) activate the fatty acids with CoASH 2( break fatty acids into acetyl CoA 3) oxidize acetyl CoA into CO2 with the TCA cycle 4) ATP generation from the ETC

Question 3

How do you break a C-C bond?

Answer 3

Destabilize an acid with B-keto group.

Question 4

Amino Acids that are both glucogenic and ketogenic

Answer 4

PhIsTTT; Phenylalanine, Isoleucine, Threonine, Tyrosine, and Tryptophan

Question 5

Which amino acids are only ketogenic

Answer 5

Leucine and Lysine

Question 6

How do we hydrolyze fatty acids?

Answer 6

By the usage of lipases. Produce fatty acids and glycerol. glycerol can be shuttled into glycolysis as Dihydroxyacetone-p. Fatty acids are oxidized.

Question 7

How is Carnitine regulated?

Answer 7

Regulated by Malonyl-CoA and abundant fatty acids.

Question 8

Odd numbered fatty acids will…

Answer 8

Form Succinyl-CoA