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Biochemistry 431 > RNA interference RNAi by miRNA > Flashcards

RNA interference RNAi by miRNA Flashcards

1
Q

pri-mRNA

A

folds into a stem-loop structure

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2
Q

pri-mRNA modification

A

5’ and 3’ extensions removed from pri-mRNA by the microprocessor complex (Drosha + DGCR8) forming 3’-OH and 5’ monophosphate

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3
Q

Pre-mRNA

A

formed once 5’ and 3’ extensions are removed by the microrepressor complex. features 3’-OH and 5’ monophosphate

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4
Q

PAZ domain

A

Present on the dicer complex; binds to the 3’ end of the hairpin and dicer cleaves the pre-miRNA to produced miRNA

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Biochemistry 431 (80 decks)

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