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Biochemistry 431 > Antibiotics > Flashcards

Antibiotics Flashcards

1
Q

Puromycin

A

Mimicks tRNA. Binds to the A site in prokaryotes. 23s is the peptidyl transferase. It transfers puromycin to the growing peptide chains, takes the peptide chain away, and degrades the protein.

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2
Q

Chloramphenicol

A

prokaryotes; effects peptidyl transferase activity by binding to the A site. (example oxazolidones “synthetic”; Linzezolid)

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3
Q

Diptheria toxin

A

eukaryotes; NAD+ dependent ADP ribosylase; binds to eEF-2, which can bind GTP, but cannot undergo hydrolysis halting elongation

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4
Q

Ricin

A

eukaryotes; disrupts 28S ribosomal subunit, removes adenine preventing tRNA function, cannot undergo GTP hydrolysis; interrupts GTP hydrolysis

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Biochemistry 431 (80 decks)

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