Covalent Attachments of lipids

Question 1

What is the purpose of attaching lipids to proteins?

Answer 1

typically to target proteins to the cell membrane.

Question 2

Acylation

Answer 2

addition of fatty acid groups; myristoyl (N of glycine) and palmitoyl groups (cysteine of C terminus) ; myristoyl strong bond

Question 3

Prenylation

Answer 3

addition of an isoprenoid group; strong; GTP binding proteins involved in signaling

Question 4

GPI anchors

Answer 4

weak; phosphatodylinositol + glycan +lipid group

Question 5

Ras

Answer 5

Signaling GTPase; both farnesylated and palmitoylated; if both are present goes to cell membrane; if only farnsylated, golgi body.