Systemic Lupus Erythematosus Therapeutics

Question 0

Cutaneous, joint SLE

Answer 0

Anti inflammatory dose of NSAIDs
Hydroxychloroquine

Warfarin for vascular occlusions

Question 1

SLE

Answer 1

Prevalent in women

Treatment depends on organ affected

Question 2

Treatment of thrombocytopenia and hemolytic anemia

Answer 2

Glucocorticosteroids

If refractory
IGG- collection of population antibodies

Question 3

SLE lupus nephritis

Answer 3

Monitor creatinine and clearance

Mild-mod: prednisone + azathioprine

Severe IV cyclophosphamide (pulse monthly)

Mycophenolate has less side effects in long term treatment

Tacrolimus if refractory

Question 4

Neuropsychiatric SLE

Answer 4

Prednisone + oral cyclophosphamide
Or IV cyclophosphamide

Rituximab if refractory

Question 5

Gout and hyperuricemia (high uric acid in blood) UA>7

Answer 5

Urate crystals in synovial of joint
Under secretion of uric acid in the kidney

Inhibition if tubular secretion may be due to alcohol, aspirin, thiazides

Dehydration may result in acute attack

Question 6

Treatment for gout/hyperuricemia

Answer 6

Colchicine - prophylaxis&acute
Prednisone-acute
Pegloticase-acute

Allopurinol, febuxostat - inhibit xanthine oxidase metabolism to uric acid