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Naplex Formulas Flashcards

1
Q

IBW men

Use IBW to dose hydrophilic drugs

A

50kg + 2.3 kg/inch > 5ft

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2
Q

IBW women

A

45.5kg + 2.3 kg/in > 5ft

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3
Q

Creatinine Clearance

A

CrCl = (140-age)(kg)/(72Scr) x 0.85 if female

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4
Q

BMI

A

Kg/m2

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5
Q

Adj body weight for obese/overweight

A

AdjBW= IBW + 0.4(TBW-IBW)

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6
Q

Obese

A

BMI > 30 or 130% IBW

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7
Q

Theophylline

A

Always dose by IBW

1 Aminophylline = 0.8 Theophylline

0.8 theophylline / 1 Aminophylline

Aminophylline prodrug x 0.8 = theophylline

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8
Q

Specific gravity

A

Grams/mL

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9
Q

PS PORCS

A

Strong inducers

Phenytoin
Smoking

Phenobarbital 
Oxcarbazepine
Rifampin
Carbamazepine
St John's Wort
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10
Q

G PACMAN

A

Strong inhibitors

Grapefruit

Protease inhibitors
Azole antifungals
Cyclosporine and cimetidine 
Macrolides (clarithromycin, erythromycin)
Amiodarone
NonDHP CCB - diltiazem, verapamil
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11
Q

SLUDGE

A

Cholinergic effects

Salivation
Lacrimation 
Urination
Diarrhea
GI distress
Emesis 
Miosis (constrict)

Organophosphate toxicity treat with Atropine (ACh blocker) and pralidoxime relieve respiratory paralysis

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12
Q

Dextrose only (typically 5%)

ABDO Synercid PL

A 
Ampho B
Bactrim 
Dalbavancin, oritavancin
Quinupristin/dalfopristin
Pentamidine (Pentam)

Lorazepam

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13
Q

Saline only (typically 0.9%)

ACDE PI

A 
Ampicillin 
Ampicillin Sulbactam (Unasyn)
Capsofungin (or LR), Cancidas
Daptomycin (or LR), Cubicin
Ertapenem (Invanz)

Phenytoin
Infliximab (Remicade)

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14
Q

Do not refrigerate these IV formulations

ABCMMP

A 
Acyclovir
Bactrim
Clindamycin
Metronidazole 
Moxifloxacin

Phenylephrine

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15
Q

Require light protection

DEMN

A 
Dopamine
Doxycycline 
Linezolid
Metronidazole 
Nitroprusside 
Norepinephrine 
Phytonadione (vitamin K)
Bactrim 
Verapamil
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16
Q

Live vaccines

A 
Measles Mumps Rubella MMR
MMRV
varicella 
Zoster (shingles)
Yellow fever 
LAIV
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17
Q

mEq

A

mEq = mmol x valence

Valence = charge of cation Na1 Ca2

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18
Q

Live vaccines

A 
Measles Mumps Rubella MMR
MMRV
varicella 
Zoster (shingles)
Yellow fever
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19
Q

Fahrenheit to Celsius

A

F = 1.8C + 32

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20
Q

Dextrose calories

A

3.4 kcal/gram

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21
Q

10% fat emulsion

A

1.1 kcal/mL

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22
Q

E value isotonicity

A

Measure total g of Na needed (total volume of 0.9%NS)

E = 58.8 i / (1.8)MW

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23
Q

1 Grain

A

65 mg

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24
Q

1 gallon

A 
4 quarts
8 pints (473 mL)
25
Q

Diphtheria, tetanus, pertussis

A

Dtap series 6months to 6yo
Tdap one time booster age 7-10 or 11-64
Td booster every 10 years after Tdap

Tdap can be given for another time in pregnant 3rd trimester

26
Q

1:1000

Ratio strength

1:XXXXXX

A

1g/1000 mL or 0.1%

  1. 1g/100mL
    1: 200,000

1g/200,000mL

27
Q

Wt/wt x spec gravity

Spec grav = g/mL

A

Wt/volume

48%w/w = g/100g

48%w/v = g/100mL

Volume x spec grav = weight

28
Q

CaCl2 milliOsmoles

A

3 milliOsmoles per mmol

H20 does not count

29
Q

Isotonic

A

0.9% NaCl = 9g/100mL

Drug x E-value = Na equivalent

Na divide E-value = drug equivalent to Na

30
Q

Henderson hasselbach

A

pH = pKa + log[salt/acid]

31
Q

Vd (in Liters)

32
Q

HLA-B 1502 positive

A

Don’t use carbamazepine

33
Q

HLAB 5701 positive

A

Don’t use abacavir (ziagen) or Trizivir (abacavir, lamivudine, zidovudine)

34
Q

HLAB 5801 positive

A

Don’t use allopurinol

35
Q

Metabolic acidosis/alkalosis

A

Low/high bicarbonate HCO3

If acidotic lungs blow off more CO2 to compensate

36
Q

Respiratory Acidosis/alkalosis

A

High/low PaCO2

CO2 to carbonic acid

If acidotic blow off CO2 to lower acid

Alkibize urine by increasing sodium bicarbonate

37
Q

NPH BID to Lantus QD

A

80% NPH = Lantus once daily

All other insulin conversions 1:1

38
Q

Corrected calcium

A

Calcium + (4-albumin)0.8

39
Q

Levothyroxine (Synthroid) IV:PO ratio

40
Q

Most antibiotics take with food to decrease GI upset except those taken on an empty stomach

APV

A 
Ampicillin 
Azithromycin ER oral suspension
Ceftibutin suspension
Levofloxacin oral solution
Metronidazole ER
Penicillin
Itraconazole solution
Voriconazole

Efavirenz

41
Q

Oral:IV 1:1

A 
Levofloxacin, moxifloxacin
Doxycycline, minocycline
Bactrim
Linezolid, tedizolid 
Metronidazole
Fluconazole, posaconazole, voriconazole
42
Q

Light protection required

DEMN

A 
Doxycycline, Dopamine
Epoprostenol (Flolan)
Micafungin (Mycamine), Metronidazole (Flagyl)
Nitroprusside (Nitropress)
Norepinephrine (Levophed)

Amiodarone
Amphotericin B
Pentamidine

Linezolid
Phytonadione
Bactrim
Verapamil

43
Q

Refrigerate after reconstitution

A 
Penicillin VK
Ampicillin
Augmentin
Cephalexin (keflex)
Cefprozil (Cefzil)
Cefuroxime(Ceftin)
Oral vancomycin
Valacyclovir

Amoxicillin for improved taste

44
Q

Do not refrigerate after reconstitution

Refrigerate beta-lactams and except for

A 
Cefdinir (Omnicef)
Azothromycin (Zmax)
Clarithromycin (Biaxin)
Doxycycline (vibramycin)
Ciprofloxacin (Cipro)
Levofloxacin (Levaquin)
Clindamycin (Cleocin)
Linezolid (Zyvox)
Bactrim 
Fluconazole (Diflucan)
Posaconazole (Noxafil)
Voriconazole (Vfend)
45
Q

Drugs that require filters (commonly 0.22 micron)

AAA DD LL PI

A 
Abatacept (Orencia)
Abciximab (ReoPro)
Albumin
Amiodarone
Ampho B Liposomal
Diazepam (Valium)
Digoxin (Digifab)
Infliximab (Remicade)
Golimumab (Simponi)
Lipids (IVFE, 0.12 microns)
Lorazepam (Ativan)
Mannitol (Osmitrol)
Phenytoin (Dilantin)
Parenteral Nutrition

Propofol (no less than 5 micron)

46
Q

Drugs that leach into PVC (use polyolefin or glass

A 
Tacrolimus 
Temsirolimus 
Cabazitaxel
Docetaxel 
Paclitaxel
Etoposide 
Ixabepilone
47
Q

Do not refrigerate these IV agents

ABCDFH

A 
IV APAP (Ofirmev)
Acyclovir - (Zovirax)
Bactrim 
Clindamycin
Deferoxamine
Furosemide 
Hydralazine
Metronidazole 
Pentamidine 
Moxifloxacin 
Phenytoin 
Phenylephrine

Marinol (dronabinol) capsules
Esomeprazole

48
Q

Store at room temperature

PED

A

Dexmedetomidine (Precedex)
Enoxaparin (Lovenox)
Propofol (Diprivan)

49
Q

Drugs that discolor urine

A 
Rifampin
Phenazopyridine 
Nitrofurantoin 
Metronidazole
Cinemet (levodopa)
Entacapone (Comtan)
50
Q

Sorption avoid PVC(DEHP) use polyolefin or glass

CLAN SIT

A 
Amiodarone (2hr infusion or greater)
Carmustine 
Lorazepam 
Sufentanil
Thiopental
Regular insulin
Nitroglycerin
51
Q

Steroid strengths

A 
Cortisone 25
Hydrocortisone 20
Prednisone/prednisolone 5
Methylprednisolone/triamcinolone 4
Dexamethasone 0.75
Betamethosone 0.6

Fluocinolone low
Mometasone med
Fluocinonide high
Clobetasol very high

52
Q

Take on empty stomach

AVOE

A 
Ampicillin 
Efavirenz (Sustiva)
Bisphosphonates 
Didanosine (Videx)
PPI before eating 
Levothyrodine 30 min before breakfast
Voriconazole 
Opana (oxymorphone)
53
Q

Take with food

A 
Atazanavir (bananavir, Reyataz)
Rilpivirine (Edurant)
Ritonavir (Norvir)
Carvedilol
Itraconazole (sporanox)
Metformin
Mevacor 
Niaspan 
Lopid 
Opioids
54
Q

Anticholinergic

A

BLURDC

Blurry vision
Mydriasis (dilate fight or flight)
Urinary retention
Dry mouth
Constipation
55
Q

Diuretic potency

A

Ethacrynic Acid (Edecrin) 50
Furosemide (Lasix) 40
Torsemide (Desmedex) 20
Bumetanide (Bumex) 1

56
Q

Sulfa

A 
Bactrim,Septra
Erythromycin-sulfisoxazole (Pediazole)
Sulfasalazine (Azulfidine)
Furosemide
Celebrex 
Dapsone 
Sumatriptan
Glyburide
57
Q

Statin potencies

A

High - rosuvastatin 20-40
Mod - 5-10

Low Simva 10 and below

58
Q

PPI conversion

A

Pantoprazole (Protonix) 40
Lansoprazole (Prevacid) 30
Omepraxole/esomeprazole 20
Rabeprazile (Aciphex) 20

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