Naplex Formulas Flashcards
1
Q
IBW men
Use IBW to dose hydrophilic drugs
A
50kg + 2.3 kg/inch > 5ft
2
Q
IBW women
A
45.5kg + 2.3 kg/in > 5ft
3
Q
Creatinine Clearance
A
CrCl = (140-age)(kg)/(72Scr) x 0.85 if female
4
Q
BMI
A
Kg/m2
5
Q
Adj body weight for obese/overweight
A
AdjBW= IBW + 0.4(TBW-IBW)
6
Q
Obese
A
BMI > 30 or 130% IBW
7
Q
Theophylline
A
Always dose by IBW
1 Aminophylline = 0.8 Theophylline
0.8 theophylline / 1 Aminophylline
Aminophylline prodrug x 0.8 = theophylline
8
Q
Specific gravity
A
Grams/mL
9
Q
PS PORCS
A
Strong inducers
Phenytoin
Smoking
Phenobarbital Oxcarbazepine Rifampin Carbamazepine St John's Wort
10
Q
G PACMAN
A
Strong inhibitors
Grapefruit
Protease inhibitors Azole antifungals Cyclosporine and cimetidine Macrolides (clarithromycin, erythromycin) Amiodarone NonDHP CCB - diltiazem, verapamil
11
Q
SLUDGE
A
Cholinergic effects
Salivation Lacrimation Urination Diarrhea GI distress Emesis Miosis (constrict)
Organophosphate toxicity treat with Atropine (ACh blocker) and pralidoxime relieve respiratory paralysis
12
Q
Dextrose only (typically 5%)
ABDO Synercid PL
A
Ampho B Bactrim Dalbavancin, oritavancin Quinupristin/dalfopristin Pentamidine (Pentam)
Lorazepam
13
Q
Saline only (typically 0.9%)
ACDE PI
A
Ampicillin Ampicillin Sulbactam (Unasyn) Capsofungin (or LR), Cancidas Daptomycin (or LR), Cubicin Ertapenem (Invanz)
Phenytoin
Infliximab (Remicade)
14
Q
Do not refrigerate these IV formulations
ABCMMP
A
Acyclovir Bactrim Clindamycin Metronidazole Moxifloxacin
Phenylephrine
15
Q
Require light protection
DEMN
A
Dopamine Doxycycline Linezolid Metronidazole Nitroprusside Norepinephrine Phytonadione (vitamin K) Bactrim Verapamil
16
Q
Live vaccines
A
Measles Mumps Rubella MMR MMRV varicella Zoster (shingles) Yellow fever LAIV
17
Q
mEq
A
mEq = mmol x valence
Valence = charge of cation Na1 Ca2
18
Q
Live vaccines
A
Measles Mumps Rubella MMR MMRV varicella Zoster (shingles) Yellow fever
19
Q
Fahrenheit to Celsius
A
F = 1.8C + 32
20
Q
Dextrose calories
A
3.4 kcal/gram
21
Q
10% fat emulsion
A
1.1 kcal/mL
22
Q
E value isotonicity
A
Measure total g of Na needed (total volume of 0.9%NS)
E = 58.8 i / (1.8)MW
23
Q
1 Grain
A
65 mg
24
Q
1 gallon
A
4 quarts 8 pints (473 mL)
25
Diphtheria, tetanus, pertussis
Dtap series 6months to 6yo
Tdap one time booster age 7-10 or 11-64
Td booster every 10 years after Tdap
Tdap can be given for another time in pregnant 3rd trimester
26
1:1000
Ratio strength
1:XXXXXX
1g/1000 mL or 0.1%
0. 1g/100mL
1: 200,000
1g/200,000mL
27
Wt/wt x spec gravity
Spec grav = g/mL
Wt/volume
48%w/w = g/100g
48%w/v = g/100mL
Volume x spec grav = weight
28
CaCl2 milliOsmoles
3 milliOsmoles per mmol
H20 does not count
29
Isotonic
0.9% NaCl = 9g/100mL
Drug x E-value = Na equivalent
Na divide E-value = drug equivalent to Na
30
Henderson hasselbach
pH = pKa + log[salt/acid]
31
Vd (in Liters)
Dose/Cp
32
HLA-B 1502 positive
Don't use carbamazepine
33
HLAB 5701 positive
Don't use abacavir (ziagen) or Trizivir (abacavir, lamivudine, zidovudine)
34
HLAB 5801 positive
Don't use allopurinol
35
Metabolic acidosis/alkalosis
Low/high bicarbonate HCO3
If acidotic lungs blow off more CO2 to compensate
36
Respiratory Acidosis/alkalosis
High/low PaCO2
CO2 to carbonic acid
If acidotic blow off CO2 to lower acid
Alkibize urine by increasing sodium bicarbonate
37
NPH BID to Lantus QD
80% NPH = Lantus once daily
All other insulin conversions 1:1
38
Corrected calcium
Calcium + (4-albumin)0.8
39
Levothyroxine (Synthroid) IV:PO ratio
0. 75:1
| 3: 4
40
Most antibiotics take with food to decrease GI upset except those taken on an empty stomach
APV
```
Ampicillin
Azithromycin ER oral suspension
Ceftibutin suspension
Levofloxacin oral solution
Metronidazole ER
Penicillin
Itraconazole solution
Voriconazole
```
Efavirenz
41
Oral:IV 1:1
```
Levofloxacin, moxifloxacin
Doxycycline, minocycline
Bactrim
Linezolid, tedizolid
Metronidazole
Fluconazole, posaconazole, voriconazole
```
42
Light protection required
DEMN
```
Doxycycline, Dopamine
Epoprostenol (Flolan)
Micafungin (Mycamine), Metronidazole (Flagyl)
Nitroprusside (Nitropress)
Norepinephrine (Levophed)
```
Amiodarone
Amphotericin B
Pentamidine
Linezolid
Phytonadione
Bactrim
Verapamil
43
Refrigerate after reconstitution
```
Penicillin VK
Ampicillin
Augmentin
Cephalexin (keflex)
Cefprozil (Cefzil)
Cefuroxime(Ceftin)
Oral vancomycin
Valacyclovir
```
Amoxicillin for improved taste
44
Do not refrigerate after reconstitution
Refrigerate beta-lactams and except for
```
Cefdinir (Omnicef)
Azothromycin (Zmax)
Clarithromycin (Biaxin)
Doxycycline (vibramycin)
Ciprofloxacin (Cipro)
Levofloxacin (Levaquin)
Clindamycin (Cleocin)
Linezolid (Zyvox)
Bactrim
Fluconazole (Diflucan)
Posaconazole (Noxafil)
Voriconazole (Vfend)
```
45
Drugs that require filters (commonly 0.22 micron)
AAA DD LL PI
```
Abatacept (Orencia)
Abciximab (ReoPro)
Albumin
Amiodarone
Ampho B Liposomal
Diazepam (Valium)
Digoxin (Digifab)
Infliximab (Remicade)
Golimumab (Simponi)
Lipids (IVFE, 0.12 microns)
Lorazepam (Ativan)
Mannitol (Osmitrol)
Phenytoin (Dilantin)
Parenteral Nutrition
```
Propofol (no less than 5 micron)
46
Drugs that leach into PVC (use polyolefin or glass
```
Tacrolimus
Temsirolimus
Cabazitaxel
Docetaxel
Paclitaxel
Etoposide
Ixabepilone
```
47
Do not refrigerate these IV agents
ABCDFH
```
IV APAP (Ofirmev)
Acyclovir - (Zovirax)
Bactrim
Clindamycin
Deferoxamine
Furosemide
Hydralazine
Metronidazole
Pentamidine
Moxifloxacin
Phenytoin
Phenylephrine
```
Marinol (dronabinol) capsules
Esomeprazole
48
Store at room temperature
PED
Dexmedetomidine (Precedex)
Enoxaparin (Lovenox)
Propofol (Diprivan)
49
Drugs that discolor urine
```
Rifampin
Phenazopyridine
Nitrofurantoin
Metronidazole
Cinemet (levodopa)
Entacapone (Comtan)
```
50
Sorption avoid PVC(DEHP) use polyolefin or glass
CLAN SIT
```
Amiodarone (2hr infusion or greater)
Carmustine
Lorazepam
Sufentanil
Thiopental
Regular insulin
Nitroglycerin
```
51
Steroid strengths
```
Cortisone 25
Hydrocortisone 20
Prednisone/prednisolone 5
Methylprednisolone/triamcinolone 4
Dexamethasone 0.75
Betamethosone 0.6
```
Fluocinolone low
Mometasone med
Fluocinonide high
Clobetasol very high
52
Take on empty stomach
AVOE
```
Ampicillin
Efavirenz (Sustiva)
Bisphosphonates
Didanosine (Videx)
PPI before eating
Levothyrodine 30 min before breakfast
Voriconazole
Opana (oxymorphone)
```
53
Take with food
```
Atazanavir (bananavir, Reyataz)
Rilpivirine (Edurant)
Ritonavir (Norvir)
Carvedilol
Itraconazole (sporanox)
Metformin
Mevacor
Niaspan
Lopid
Opioids
```
54
Anticholinergic
BLURDC
```
Blurry vision
Mydriasis (dilate fight or flight)
Urinary retention
Dry mouth
Constipation
```
55
Diuretic potency
Ethacrynic Acid (Edecrin) 50
Furosemide (Lasix) 40
Torsemide (Desmedex) 20
Bumetanide (Bumex) 1
56
Sulfa
```
Bactrim,Septra
Erythromycin-sulfisoxazole (Pediazole)
Sulfasalazine (Azulfidine)
Furosemide
Celebrex
Dapsone
Sumatriptan
Glyburide
```
57
Statin potencies
High - rosuvastatin 20-40
Mod - 5-10
Low Simva 10 and below
58
PPI conversion
Pantoprazole (Protonix) 40
Lansoprazole (Prevacid) 30
Omepraxole/esomeprazole 20
Rabeprazile (Aciphex) 20
