Antiviral Medchem Flashcards by Nicholas Leung | Brainscape

Q

Cidfovir ganciclovir foscarnet

A

DNA polymerase

Foscarnet mimic pyrophosphate

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Q

Acyclovir

A

Thymidine kinase

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Q

Amantadine

Rimantidine

A

Block M2 uncoating of virus particle and release of viral RNA

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Q

Zanamivir

Oseltamivir

A

Transition state inhibitor of neuraminidase/sialidase

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Q

Ribavirin hep C

A

Inhibit inosine mono phosphate dehydrogenase

Cause decrease in GTP

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Q

DNA viruses

A

HSV, Varicella zoster, HepB

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Q

RNA viruses

A

HIV, influenza, HepACE

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Q

Bocepravir, telaprevir

A

Inhibit hepC serine protease

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Q

Maraviroc (selzentry)

A

Chemokine receptor CCR5 antagonist

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Q

Enfuviritide (fuzeon)

A

Mimic gp41 HR-2 needed for viral fusion zipping

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Q

Quinolines: chloroquine, mefloquine

A

Interfere with hemoglobin/heme

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Q

Atovaquine + proguanil (malarone)

A

Inhibit dihydrofolate reductase DHFR

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Q

Artemisinin

A

Endoperoxide o-o free radical

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Q

Free radical mechanism

A

Artemisinin, metronidazole, isoniazid,

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Q

Rifamycin

A

Block RNA polymerase

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Q

Pyrazinamide

A

Interfere with NAD synthesis