Antifungals Flashcards by Nicholas Leung | Brainscape

Q

-azoles

A

Target 14-alpha-demethylase

Inhibit ergosterol synthesis

Ketoconazole requires acidic environment

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Q

Amphotericin B

A

Membrane disruptor

More double bonds = more potent

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Q

Allyl amines

A

Target squalene epoxidase

Terbinafine

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Q

Capsofungin

A

Echinocandrin

Inhibit cell wall synthesis

Target beta-1,3-D-glucan synthase

Use if intolerant to ampho B

No oral formulation

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