Neurotransmission Flashcards
Inhibitory neurotransmitter
GABA
Glycine
Alpha 2 agonist
Excitatory neurotransmitter
Glutamate
Aspartate
Substance P
Acetylcholine Catecholamines (dop nor epi)
Serotonin
Histamine
Pain excitatory
Prostaglandin, serotonin, substance p, histamine
Pain inhibitory
Serotonin, norepinephrine, endogenous opioids
Norepinephrine
Energy, fight or flight
Dopamine
Pleasure, reward, motor control
Schizophrenia, Parkinson’s pathophysiology
Serotonin
Mood, satisfaction
SSRI for depression
Antixiolytics
Shut down Anxiety circuits by GABA stimulation
Flumazenil
Benzo antagonist for BDZ overdose
Block BDZs, zolpidem, lunesta
Picrotoxin
Block Cl- pore
Reverse barbiturate, benzo effects
Locus ceruleus
Source of NE neurons nonadrenergic
Raphe nuclei
Source if serotonergic neurons
Ramelteon
Melatonin receptor agonist
Hypnotic
Sonata, zolpidem (ambien)
Non BDZ structure hypnotic
Buspirone
Selective anti-anxiety
Drugs that produce depression
AMPT
Reserpine
Tetrabenazine
Drugs that relieve depression
Amphetamines
Iproniazid (MAO inhibitors)
Imipramine (reuptake inhibitors)
SSRI
Escitalopram, fluoxetine, sertraline
SNRI
Fluoxetine (cymbalta)
Venlafaxine (Effexor)
NDRI
Bupropion
NRI
Reboxetine
Tricyclic antidepressant
First generation
Nortriptyline
Desipramine
Doxepin
Amitriptyline
Imipramine
First generation antipsychotic
Dopamine antagonists
Sexual dysfunction
Extrapyramidal symptoms
Haloperidol
Chlorpromazine
Fluphenazine
Thioridazine
Second generation antipsychotic
Metabolic side effects
Olanzapine
Quetiapine
Risperidone
Aripiprazole
Clozapine
For treatment resistant schizophrenia
Cationic site
Lysine
An ionic site
Glutamate
Hydrophobic site
Gly ala phenylala
GAP
OCD
Clomipramine
Valproic acid
Mania
Steven Johnson syndrome
Carbamazepine
Lamotrigine - good for depression in bipolar
Mood stabilizer
Lithium
Carbamazepine
Valproic acid
Felbamate
Lennox gasteaut
FN KAT
F NMDA antagonist
Status epilepticus
Lorazepam
Topiramate
Seizures and alcohol abuse
KAT kainate AMDA antagonist
Zonisamide
Sulfa allergy
