Neurotransmission Flashcards

0
Q

Inhibitory neurotransmitter

A

GABA
Glycine
Alpha 2 agonist

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1
Q

Excitatory neurotransmitter

A

Glutamate
Aspartate
Substance P

Acetylcholine 
Catecholamines (dop nor epi)

Serotonin
Histamine

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2
Q

Pain excitatory

A

Prostaglandin, serotonin, substance p, histamine

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3
Q

Pain inhibitory

A

Serotonin, norepinephrine, endogenous opioids

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4
Q

Norepinephrine

A

Energy, fight or flight

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5
Q

Dopamine

A

Pleasure, reward, motor control

Schizophrenia, Parkinson’s pathophysiology

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6
Q

Serotonin

A

Mood, satisfaction

SSRI for depression

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7
Q

Antixiolytics

A

Shut down Anxiety circuits by GABA stimulation

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8
Q

Flumazenil

A

Benzo antagonist for BDZ overdose

Block BDZs, zolpidem, lunesta

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9
Q

Picrotoxin

A

Block Cl- pore

Reverse barbiturate, benzo effects

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10
Q

Locus ceruleus

A

Source of NE neurons nonadrenergic

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11
Q

Raphe nuclei

A

Source if serotonergic neurons

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12
Q

Ramelteon

A

Melatonin receptor agonist

Hypnotic

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13
Q

Sonata, zolpidem (ambien)

A

Non BDZ structure hypnotic

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14
Q

Buspirone

A

Selective anti-anxiety

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15
Q

Drugs that produce depression

A

AMPT
Reserpine
Tetrabenazine

16
Q

Drugs that relieve depression

A

Amphetamines
Iproniazid (MAO inhibitors)
Imipramine (reuptake inhibitors)

17
Q

SSRI

A

Escitalopram, fluoxetine, sertraline

18
Q

SNRI

A

Fluoxetine (cymbalta)

Venlafaxine (Effexor)

19
Q

NDRI

A

Bupropion

20
Q

NRI

A

Reboxetine

21
Q

Tricyclic antidepressant

A

First generation
Nortriptyline
Desipramine

Doxepin
Amitriptyline
Imipramine

22
Q

First generation antipsychotic

Dopamine antagonists

Sexual dysfunction
Extrapyramidal symptoms

A

Haloperidol
Chlorpromazine
Fluphenazine
Thioridazine

23
Q

Second generation antipsychotic

Metabolic side effects

A

Olanzapine
Quetiapine
Risperidone
Aripiprazole

24
Q

Clozapine

A

For treatment resistant schizophrenia

25
Q

Cationic site

A

Lysine

26
Q

An ionic site

A

Glutamate

27
Q

Hydrophobic site

A

Gly ala phenylala

GAP

28
Q

OCD

A

Clomipramine

29
Q

Valproic acid

A

Mania

30
Q

Steven Johnson syndrome

A

Carbamazepine

Lamotrigine - good for depression in bipolar

31
Q

Mood stabilizer

A

Lithium
Carbamazepine
Valproic acid

32
Q

Felbamate

A

Lennox gasteaut
FN KAT
F NMDA antagonist

33
Q

Status epilepticus

A

Lorazepam

34
Q

Topiramate

A

Seizures and alcohol abuse

KAT kainate AMDA antagonist

35
Q

Zonisamide

A

Sulfa allergy