Colorectal Therapeutics

Question 0

FOLFOX

Answer 0

5-FU single Bolus, continuous (risk of hand-foot) syndrome
Leucovorin
Oxaliplatin

Can add panitumumab in stage 4 metastasis if KRAS wildtype

Question 1

FLOX

Answer 1

Bolus 5-FU (risk of neutropenia)
Leucovorin
Oxaliplatin

Question 2

CAPEOX

Answer 2

Capecitabine (PO 5-FU prodrug)
Oxaliplatin

Available for adjuvant therapy for stage III colon cancer

Question 3

FOLFIRI

Answer 3

5-FU
Leucovorin
Irinotecan

Not recommended in stage 1-3!
Avoid irinotecan, bevaxizumab, cetuximab in stage 3 or lower

Can add cetuximab or panitumumab in stage 4

Question 4

FOLFIRINOX

Answer 4

5-FU
Leucovorin
Irinotecan
Oxaliplatin

Last resort

Question 5

Colorectal metastasis

Answer 5

First line oxaliplatin based regimen

Add bevacizumab

If KRAS wild type
FOLFOX (panitumumab) or FOLFIRI plus
Cetuximab or Panitumumab

Question 6

EGFR inhibitors that work with KRAS wild type

Non-mutated KRAS

Answer 6

Cetuximab

Panitumumab

Question 7

Rectal cancer

Radiation rectal

Answer 7

Chemotherapy in stage 2 due to increased risk of occurrence

Triple combination of surgery, radiation, and chemotherapy recommended for stage 2&3

Question 8

Oxaliplatin adverse effect

Answer 8

Cold induced peripheral neuropathy

Question 9

Stage 2 colon cancer low risk

Answer 9

Capecitabine

5-FU/LV

No oxaliplatin!

Question 10

Stage 2 colon cancer high risk

Answer 10

Same as low risk

Can add oxaliplatin

FOLFOX
CapeOx

Question 11

Stage 3 colon cancer

Answer 11

Use oxaliplatin based regimen

Question 12

Stage 4 colon cancer

Answer 12

1) FOLFOX
2) FOLFIRI can add bevacizumab
3) single agent