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Pharmacy > Parkinson's disease therapeutics > Flashcards

Parkinson's disease therapeutics Flashcards

0
Q

Reduce dyskinesia or tremor

A

Amantadine or

Anticholinergic - benztropine, diphenhydramine

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1
Q

Add to reduce off time

A

Entacapone (comt inhibitor)

Rasagiline (Mao inhibitor)

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2
Q

Surgery

A

Deep brain stimulation of subthalamic nucleus

Thalamoty - dyskinesia, tremor, rigidity
Pallidomy- on off, fluctuations

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3
Q

Young Parkinson’s patient

A

Dopamine agonist

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4
Q

Older patient

A

Start with levodopa

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5
Q

D1 adverse agonism

A

Link to dyskinesia

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6
Q

D2 adverse agonism

A

Hallucinations, psychosis

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7
Q

Psychosis in PD

A

Titrate PD therapy down

(Anticholinergic, selegiline, amantadine, dop agonist, COMT, levo dopa)

Clozapine, quetiapine

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8
Q

Dementia in PD

A

Rivastigmine

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9
Q

Dopamine 2 selective agonists

A

Pramipexole

Ropinirole

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