Alzheimer's Therapeutics

Question 0

Treat Alzheimer’s

Answer 0

Anticholinesterase inhibitors - increase acetylcholine

Donepezil - 1st line. good for mild-severe

rivastigmine - only for mild-mod

Side effects: NVD, bradycardia

Question 1

Anticholinergics

Answer 1

Benztropine, diphenhydramine, oxybutynin, flexeril

May increase confusion and cognitive impairment in AD; blurry vision, urinary retention, dry mouth, constipation

3C BUD

Question 2

Glutamate excitotoxicity

Answer 2

Namenda-NMDA antagonist

Question 3

Behavioral psychological symptoms of dementia

Answer 3

Reduce stressful environment
Orientation aids
Create a routine
Animals music aroma therapy

Some efficacy and risk with atypical antipsychotics - olanzapine, quetiapine
Monitor and try to lower in 3 months