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Pharma > Sulfonamides, Trimethoprim, and Fluoroquinolones > Flashcards

Sulfonamides, Trimethoprim, and Fluoroquinolones Flashcards

0
Q

Trimethoprim-sulfamethoxazole

A

Folate antagonist

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1
Q

Folate antagonist

A

Trimethoprim-sulfamethoxazole

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2
Q

Trimethoprim-sulfamethoxazole

Mechanism of action

A

Synergistic combination of folate antagonists blocks purine production and nucleic acid synthesis

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3
Q

Synergistic combination of folate antagonists blocks purine production and nucleic acid synthesis

A

Trimethoprim-sulfamethoxazole

Mechanism of action

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4
Q

Trimethoprim-sulfamethoxazole

Effects

A

Bactericidal activity against susceptible bacteria

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5
Q

Trimethoprim-sulfamethoxazole

Clinical applications

A

Urinary tract infections, P jiroveci pneumonia, toxoplasmosis, nocardiosis

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6
Q

Urinary tract infections, P jiroveci pneumonia, toxoplasmosis, nocardiosis

A

Trimethoprim-sulfamethoxazole

Clinical applications

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7
Q

Fluoroquinolones

A 
Ciprofloxacin
Ofloxacin
Levofloxacin
Moxifloxacin
Gemifloxacin
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8
Q 
Ciprofloxacin
Ofloxacin
Levofloxacin
Moxifloxacin
Gemifloxacin
A

Fluoroquinolones

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9
Q

Ciprofloxacin
(fluoroquinolones)

Mechanism of action

A

Inhibits DNA replication by binding to DNA gyrase and topoisomerase IV

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10
Q

Fluoroquinolones

A

Ciprofloxacin
(fluoroquinolones)

Mechanism of action

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11
Q

Ciprofloxacin
(fluoroquinolones)

Effects

A

Bactericidal activity against susceptible bacteria

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12
Q

Bactericidal activity against susceptible bacteria

A

Ciprofloxacin
(fluoroquinolones)

Effects

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13
Q

Ciprofloxacin
(fluoroquinolones)

Clinical applications

A

Urinary tract infections, gastroenteritis, osteomyelitis, anthrax

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14
Q

Urinary tract infections, gastroenteritis, osteomyelitis, anthrax

A

Ciprofloxacin
(fluoroquinolones)

Clinical applications

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15
Q

Ofloxacin

A

Oral; has improved pharmacokinetics and pharmacodynamics; use is limited to urinary tract infections and nongonococcal urethritis and cervicitis

16
Q

Oral; has improved pharmacokinetics and pharmacodynamics; use is limited to urinary tract infections and nongonococcal urethritis and cervicitis

A

Ofloxacin

17
Q

Levofloxacin

A

Oral, IV; L-isomer of ofloxacin; once-daily dosing; renal clearance; “respiratory” fluoroquinolone with improved activity versus pneumococcus

18
Q

Oral; has improved pharmacokinetics and pharmacodynamics; use is limited to urinary tract infections and nongonococcal urethritis and cervicitis

A

Levofloxacin

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