Hypothalamic & Pituitary Hormones Flashcards
Somatropin
Growth hormone (GH)
Growth hormone (GH)
Somatropin
Somatropin
Mechanism of action
Recombinant forms of human GH - acts through GH receptors to increase production of IGF-1
Recombinant forms of human GH - acts through GH receptors to increase production of IGF-1
Somatropin
Mechanism of action
Somatropin
Effects
Restores normal growth and metabolic GH effects in GH-deficient individuals.
Increases final adult height in some children with short stature not due to GH deficiency
Restores normal growth and metabolic GH effects in GH-deficient individuals.
Increases final adult height in some children with short stature not due to GH deficiency
Somatropin
Effects
Somatropin
Clinical application
Replacement in GH deficiency.
Increased final adult height in children with certain conditions associated with short stature.
Wasting in HIV infection.
Short bowel syndrome
Replacement in GH deficiency.
Increased final adult height in children with certain conditions associated with short stature.
Wasting in HIV infection.
Short bowel syndrome
Somatropin
Clinical application
Somatropin
Toxicity
Pseudotumor cerebri Slipped capital femoral epiphysis Edema Hyperglycemiaj Progression of scoliosis Sleep apnea
Pseudotumor cerebri Slipped capital femoral epiphysis Edema Hyperglycemiaj Progression of scoliosis Sleep apnea
Somatropin
Toxicity
Somatostatin analogs
Octreotide
Lanreotide
Lanreotide
Somatostatin analog
Octreotide
Somatostatin analog
Octreotide
Mechanism of action
Agonist at somatostatin receptors
Agonist at somatostatin receptors
Octreotide
Mechanism of action
Octreotide
Effects
Inhibits production of GH and, to a lesser extent, of TSH, glucagon, insulin, and gastrin
Inhibits production of GH and, to a lesser extent, of TSH, glucagon, insulin, and gastrin
Octreotide
Effects
Octreotide
Clinical applications
Acromegaly and several other hormone-secreting tumors
Acute control of bleeding from esophageal varices
Acromegaly and several other hormone-secreting tumors
Acute control of bleeding from esophageal varices
Octreotide
Clinical applications
Octreotide
Toxicity
Gastrointestinal disturbance
Gallstones
Bradycardia
Cardiac conduction problems
Gastrointestinal disturbance
Gallstones
Bradycardia
Cardiac conduction problems
Octreotide
Toxicity
GH receptor antagonist
Pegvisomant
Pegvisomant
GH receptor antagonist
Pegvisomant
Mechanism of action
Blocks GH receptors
Blocks GH receptors
Pegvisomant
Mechanism of action
Pegvisomant
Effects
Ameliorates effects of excess GH production
Ameliorates effects of excess GH production
Pegvisomant
Effects
Pegvisomant
Clinical applications
Acromegaly
Acromegaly
Pegvisomant
Clinical applications
Pegvisomant
Toxicity
Increased liver enzymes
Increased liver enzymes
Pegvisomant
Toxicity
Gonadotropins: Follicle-stimulating hormone (FSH) analogs
Follitropin alpa
Follitropin beta
Urofollitropin
Menotropins
Follitropin alpa
Gonadotropin: Follicle-stimulating hormone (FSH) analog
Follitropin beta
Gonadotropin: Follicle-stimulating hormone (FSH) analog
A recombiant product with the same peptide sequence as follitropin alfa but differs in carbohydrate side chains
Urofollitropin
Gonadotropin: Follicle-stimulating hormone (FSH) analog
Human FSH purified from urine of postmenopausal women
Menotropins
Gonadotropin: Follicle-stimulating hormone (FSH) analog
(hMG) :Extract of the urine of postmenopausal women; contains both FSH and LH activity
Gonadotropin: Follicle-stimulating hormone (FSH) analog
A recombiant product with the same peptide sequence as follitropin alfa but differs in carbohydrate side chains
Follitropin beta
Gonadotropin: Follicle-stimulating hormone (FSH) analog
Human FSH purified from urine of postmenopausal women
Urofollitropin
Gonadotropin: Follicle-stimulating hormone (FSH) analog
(hMG) :Extract of the urine of postmenopausal women; contains both FSH and LH activity
Menotropins
Follitropin alpa
Mechanism of action
Activates FSH receptors
Activates FSH receptors
Follitropin alpa
Mechanism of action
Follitropin alpa
Effects
Mimics effects of endogenous FSH
Mimics effects of endogenous FSH
Follitropin alpa
Effects
Follitropin alpa
Clinical applications
Controlled ovulation hyperstimulation in women
Infertility due to hypogonadotropic hypogonadism in men
Controlled ovulation hyperstimulation in women
Infertility due to hypogonadotropic hypogonadism in men
Follitropin alpa
Clinical applications
Follitropin alpa
Toxicity
Ovarian hyperstimulation syndrome and multiple pregnancies in women
Gynecomastia in men
Headache, Depression, Edema in both sexes
Ovarian hyperstimulation syndrome and multiple pregnancies in women
Gynecomastia in men
Headache, Depression, Edema in both sexes
Follitropin alpa
Toxicity
Gonadotropins:Luteinzing hormone (LH) analogs
Human chorionic gonadotropin (hCG)
Choriogonadotropin alpa
Lutropin
Menotropins (hMG)
Human chorionic gonadotropin (hCG)
Gonadotropin:Luteinzing hormone (LH) analog
Choriogonadotropin alpa
Gonadotropin:Luteinzing hormone (LH) analog
Recombiant form of hCG
Lutropin
Gonadotropin:Luteinzing hormone (LH) analog
Recombinant form of human LH
Menotropins (hMG)
Gonadotropin:Luteinzing hormone (LH) analog
(hMG) :Extract of the urine of postmenopausal women; contains both FSH and LH activity
Gonadotropin:Luteinzing hormone (LH) analog
Recombiant form of hCG
Choriogonadotropin alpa
Gonadotropin:Luteinzing hormone (LH) analog
Recombinant form of human LH
Lutropin
Gonadotropin:Luteinzing hormone (LH) analog
(hMG) :Extract of the urine of postmenopausal women; contains both FSH and LH activity
Menotropins (hMG)
Human chorionic gonadotropin (hCG)
Mechanism of action
Agonist at LH receptor
Agonist at LH receptor
Human chorionic gonadotropin (hCG)
Mechanism of action
Human chorionic gonadotropin (hCG)
Effects
Mimics effects of endogenous LH
Mimics effects of endogenous LH
Human chorionic gonadotropin (hCG)
Effects
Human chorionic gonadotropin (hCG)
Clinical applications
Initiation of ovulation during controlled ovulation hyperstimulation
Ovarian follicle development in women with hypogonadotropic hypogonadism
Male hypogonadotropic hypogonadism
Initiation of ovulation during controlled ovulation hyperstimulation
Ovarian follicle development in women with hypogonadotropic hypogonadism
Male hypogonadotropic hypogonadism
Human chorionic gonadotropin (hCG)
Clinical applications
Human chorionic gonadotropin (hCG)
Toxicity
Ovarian hyperstimulation syndrom and multiple pregnancies in women
Gynecomastia in men
Headache, depression, edema in both sexes
Ovarian hyperstimulation syndrom and multiple pregnancies in women
Gynecomastia in men
Headache, depression, edema in both sexes
Human chorionic gonadotropin (hCG)
Toxicity