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Hypothalamic & Pituitary Hormones Flashcards

0
Q

Somatropin

A

Growth hormone (GH)

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1
Q

Growth hormone (GH)

A

Somatropin

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2
Q

Somatropin

Mechanism of action

A

Recombinant forms of human GH - acts through GH receptors to increase production of IGF-1

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3
Q

Recombinant forms of human GH - acts through GH receptors to increase production of IGF-1

A

Somatropin

Mechanism of action

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4
Q

Somatropin

Effects

A

Restores normal growth and metabolic GH effects in GH-deficient individuals.
Increases final adult height in some children with short stature not due to GH deficiency

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5
Q

Restores normal growth and metabolic GH effects in GH-deficient individuals.
Increases final adult height in some children with short stature not due to GH deficiency

A

Somatropin

Effects

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6
Q

Somatropin

Clinical application

A

Replacement in GH deficiency.
Increased final adult height in children with certain conditions associated with short stature.
Wasting in HIV infection.
Short bowel syndrome

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7
Q

Replacement in GH deficiency.
Increased final adult height in children with certain conditions associated with short stature.
Wasting in HIV infection.
Short bowel syndrome

A

Somatropin

Clinical application

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8
Q

Somatropin

Toxicity

A 
Pseudotumor cerebri
Slipped capital femoral epiphysis
Edema
Hyperglycemiaj
Progression of scoliosis
Sleep apnea
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9
Q 
Pseudotumor cerebri
Slipped capital femoral epiphysis
Edema
Hyperglycemiaj
Progression of scoliosis
Sleep apnea
A

Somatropin

Toxicity

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10
Q

Somatostatin analogs

A

Octreotide

Lanreotide

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11
Q

Lanreotide

A

Somatostatin analog

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12
Q

Octreotide

A

Somatostatin analog

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13
Q

Octreotide

Mechanism of action

A

Agonist at somatostatin receptors

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14
Q

Agonist at somatostatin receptors

A

Octreotide

Mechanism of action

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15
Q

Octreotide

Effects

A

Inhibits production of GH and, to a lesser extent, of TSH, glucagon, insulin, and gastrin

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16
Q

Inhibits production of GH and, to a lesser extent, of TSH, glucagon, insulin, and gastrin

A

Octreotide

Effects

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17
Q

Octreotide

Clinical applications

A

Acromegaly and several other hormone-secreting tumors

Acute control of bleeding from esophageal varices

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18
Q

Acromegaly and several other hormone-secreting tumors

Acute control of bleeding from esophageal varices

A

Octreotide

Clinical applications

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19
Q

Octreotide

Toxicity

A

Gastrointestinal disturbance
Gallstones
Bradycardia
Cardiac conduction problems

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20
Q

Gastrointestinal disturbance
Gallstones
Bradycardia
Cardiac conduction problems

A

Octreotide

Toxicity

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21
Q

GH receptor antagonist

A

Pegvisomant

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22
Q

Pegvisomant

A

GH receptor antagonist

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23
Q

Pegvisomant

Mechanism of action

A

Blocks GH receptors

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24
Blocks GH receptors
Pegvisomant | Mechanism of action
25
Pegvisomant | Effects
Ameliorates effects of excess GH production
26
Ameliorates effects of excess GH production
Pegvisomant | Effects
27
Pegvisomant | Clinical applications
Acromegaly
28
Acromegaly
Pegvisomant | Clinical applications
29
Pegvisomant | Toxicity
Increased liver enzymes
30
Increased liver enzymes
Pegvisomant | Toxicity
31
Gonadotropins: Follicle-stimulating hormone (FSH) analogs
Follitropin alpa Follitropin beta Urofollitropin Menotropins
32
Follitropin alpa
Gonadotropin: Follicle-stimulating hormone (FSH) analog
33
Follitropin beta
Gonadotropin: Follicle-stimulating hormone (FSH) analog A recombiant product with the same peptide sequence as follitropin alfa but differs in carbohydrate side chains
34
Urofollitropin
Gonadotropin: Follicle-stimulating hormone (FSH) analog Human FSH purified from urine of postmenopausal women
35
Menotropins
Gonadotropin: Follicle-stimulating hormone (FSH) analog (hMG) :Extract of the urine of postmenopausal women; contains both FSH and LH activity
36
Gonadotropin: Follicle-stimulating hormone (FSH) analog A recombiant product with the same peptide sequence as follitropin alfa but differs in carbohydrate side chains
Follitropin beta
37
Gonadotropin: Follicle-stimulating hormone (FSH) analog Human FSH purified from urine of postmenopausal women
Urofollitropin
38
Gonadotropin: Follicle-stimulating hormone (FSH) analog (hMG) :Extract of the urine of postmenopausal women; contains both FSH and LH activity
Menotropins
39
Follitropin alpa | Mechanism of action
Activates FSH receptors
40
Activates FSH receptors
Follitropin alpa | Mechanism of action
41
Follitropin alpa | Effects
Mimics effects of endogenous FSH
42
Mimics effects of endogenous FSH
Follitropin alpa | Effects
43
Follitropin alpa | Clinical applications
Controlled ovulation hyperstimulation in women | Infertility due to hypogonadotropic hypogonadism in men
44
Controlled ovulation hyperstimulation in women | Infertility due to hypogonadotropic hypogonadism in men
Follitropin alpa | Clinical applications
45
Follitropin alpa | Toxicity
Ovarian hyperstimulation syndrome and multiple pregnancies in women Gynecomastia in men Headache, Depression, Edema in both sexes
46
Ovarian hyperstimulation syndrome and multiple pregnancies in women Gynecomastia in men Headache, Depression, Edema in both sexes
Follitropin alpa | Toxicity
47
Gonadotropins:Luteinzing hormone (LH) analogs
Human chorionic gonadotropin (hCG) Choriogonadotropin alpa Lutropin Menotropins (hMG)
48
Human chorionic gonadotropin (hCG)
Gonadotropin:Luteinzing hormone (LH) analog
49
Choriogonadotropin alpa
Gonadotropin:Luteinzing hormone (LH) analog Recombiant form of hCG
50
Lutropin
Gonadotropin:Luteinzing hormone (LH) analog Recombinant form of human LH
51
Menotropins (hMG)
Gonadotropin:Luteinzing hormone (LH) analog (hMG) :Extract of the urine of postmenopausal women; contains both FSH and LH activity
52
Gonadotropin:Luteinzing hormone (LH) analog Recombiant form of hCG
Choriogonadotropin alpa
53
Gonadotropin:Luteinzing hormone (LH) analog Recombinant form of human LH
Lutropin
54
Gonadotropin:Luteinzing hormone (LH) analog (hMG) :Extract of the urine of postmenopausal women; contains both FSH and LH activity
Menotropins (hMG)
55
Human chorionic gonadotropin (hCG) | Mechanism of action
Agonist at LH receptor
56
Agonist at LH receptor
Human chorionic gonadotropin (hCG) | Mechanism of action
57
Human chorionic gonadotropin (hCG) | Effects
Mimics effects of endogenous LH
58
Mimics effects of endogenous LH
Human chorionic gonadotropin (hCG) | Effects
59
Human chorionic gonadotropin (hCG) | Clinical applications
Initiation of ovulation during controlled ovulation hyperstimulation Ovarian follicle development in women with hypogonadotropic hypogonadism Male hypogonadotropic hypogonadism
60
Initiation of ovulation during controlled ovulation hyperstimulation Ovarian follicle development in women with hypogonadotropic hypogonadism Male hypogonadotropic hypogonadism
Human chorionic gonadotropin (hCG) | Clinical applications
61
Human chorionic gonadotropin (hCG) | Toxicity
Ovarian hyperstimulation syndrom and multiple pregnancies in women Gynecomastia in men Headache, depression, edema in both sexes
62
Ovarian hyperstimulation syndrom and multiple pregnancies in women Gynecomastia in men Headache, depression, edema in both sexes
Human chorionic gonadotropin (hCG) | Toxicity

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