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Pharma > Hypothalamic & Pituitary Hormones > Flashcards

Hypothalamic & Pituitary Hormones Flashcards

0
Q

Somatropin

A

Growth hormone (GH)

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1
Q

Growth hormone (GH)

A

Somatropin

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2
Q

Somatropin

Mechanism of action

A

Recombinant forms of human GH - acts through GH receptors to increase production of IGF-1

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3
Q

Recombinant forms of human GH - acts through GH receptors to increase production of IGF-1

A

Somatropin

Mechanism of action

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4
Q

Somatropin

Effects

A

Restores normal growth and metabolic GH effects in GH-deficient individuals.
Increases final adult height in some children with short stature not due to GH deficiency

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5
Q

Restores normal growth and metabolic GH effects in GH-deficient individuals.
Increases final adult height in some children with short stature not due to GH deficiency

A

Somatropin

Effects

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6
Q

Somatropin

Clinical application

A

Replacement in GH deficiency.
Increased final adult height in children with certain conditions associated with short stature.
Wasting in HIV infection.
Short bowel syndrome

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7
Q

Replacement in GH deficiency.
Increased final adult height in children with certain conditions associated with short stature.
Wasting in HIV infection.
Short bowel syndrome

A

Somatropin

Clinical application

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8
Q

Somatropin

Toxicity

A 
Pseudotumor cerebri
Slipped capital femoral epiphysis
Edema
Hyperglycemiaj
Progression of scoliosis
Sleep apnea
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9
Q 
Pseudotumor cerebri
Slipped capital femoral epiphysis
Edema
Hyperglycemiaj
Progression of scoliosis
Sleep apnea
A

Somatropin

Toxicity

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10
Q

Somatostatin analogs

A

Octreotide

Lanreotide

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11
Q

Lanreotide

A

Somatostatin analog

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12
Q

Octreotide

A

Somatostatin analog

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13
Q

Octreotide

Mechanism of action

A

Agonist at somatostatin receptors

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14
Q

Agonist at somatostatin receptors

A

Octreotide

Mechanism of action

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15
Q

Octreotide

Effects

A

Inhibits production of GH and, to a lesser extent, of TSH, glucagon, insulin, and gastrin

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16
Q

Inhibits production of GH and, to a lesser extent, of TSH, glucagon, insulin, and gastrin

A

Octreotide

Effects

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17
Q

Octreotide

Clinical applications

A

Acromegaly and several other hormone-secreting tumors

Acute control of bleeding from esophageal varices

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18
Q

Acromegaly and several other hormone-secreting tumors

Acute control of bleeding from esophageal varices

A

Octreotide

Clinical applications

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19
Q

Octreotide

Toxicity

A

Gastrointestinal disturbance
Gallstones
Bradycardia
Cardiac conduction problems

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20
Q

Gastrointestinal disturbance
Gallstones
Bradycardia
Cardiac conduction problems

A

Octreotide

Toxicity

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21
Q

GH receptor antagonist

A

Pegvisomant

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22
Q

Pegvisomant

A

GH receptor antagonist

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23
Q

Pegvisomant

Mechanism of action

A

Blocks GH receptors

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24
Q

Blocks GH receptors

A

Pegvisomant

Mechanism of action

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25
Q

Pegvisomant

Effects

A

Ameliorates effects of excess GH production

26
Q

Ameliorates effects of excess GH production

A

Pegvisomant

Effects

27
Q

Pegvisomant

Clinical applications

A

Acromegaly

28
Q

Acromegaly

A

Pegvisomant

Clinical applications

29
Q

Pegvisomant

Toxicity

A

Increased liver enzymes

30
Q

Increased liver enzymes

A

Pegvisomant

Toxicity

31
Q

Gonadotropins: Follicle-stimulating hormone (FSH) analogs

A

Follitropin alpa
Follitropin beta
Urofollitropin
Menotropins

32
Q

Follitropin alpa

A

Gonadotropin: Follicle-stimulating hormone (FSH) analog

33
Q

Follitropin beta

A

Gonadotropin: Follicle-stimulating hormone (FSH) analog

A recombiant product with the same peptide sequence as follitropin alfa but differs in carbohydrate side chains

34
Q

Urofollitropin

A

Gonadotropin: Follicle-stimulating hormone (FSH) analog

Human FSH purified from urine of postmenopausal women

35
Q

Menotropins

A

Gonadotropin: Follicle-stimulating hormone (FSH) analog

(hMG) :Extract of the urine of postmenopausal women; contains both FSH and LH activity

36
Q

Gonadotropin: Follicle-stimulating hormone (FSH) analog

A recombiant product with the same peptide sequence as follitropin alfa but differs in carbohydrate side chains

A

Follitropin beta

37
Q

Gonadotropin: Follicle-stimulating hormone (FSH) analog

Human FSH purified from urine of postmenopausal women

A

Urofollitropin

38
Q

Gonadotropin: Follicle-stimulating hormone (FSH) analog

(hMG) :Extract of the urine of postmenopausal women; contains both FSH and LH activity

A

Menotropins

39
Q

Follitropin alpa

Mechanism of action

A

Activates FSH receptors

40
Q

Activates FSH receptors

A

Follitropin alpa

Mechanism of action

41
Q

Follitropin alpa

Effects

A

Mimics effects of endogenous FSH

42
Q

Mimics effects of endogenous FSH

A

Follitropin alpa

Effects

43
Q

Follitropin alpa

Clinical applications

A

Controlled ovulation hyperstimulation in women

Infertility due to hypogonadotropic hypogonadism in men

44
Q

Controlled ovulation hyperstimulation in women

Infertility due to hypogonadotropic hypogonadism in men

A

Follitropin alpa

Clinical applications

45
Q

Follitropin alpa

Toxicity

A

Ovarian hyperstimulation syndrome and multiple pregnancies in women
Gynecomastia in men
Headache, Depression, Edema in both sexes

46
Q

Ovarian hyperstimulation syndrome and multiple pregnancies in women
Gynecomastia in men
Headache, Depression, Edema in both sexes

A

Follitropin alpa

Toxicity

47
Q

Gonadotropins:Luteinzing hormone (LH) analogs

A

Human chorionic gonadotropin (hCG)
Choriogonadotropin alpa
Lutropin
Menotropins (hMG)

48
Q

Human chorionic gonadotropin (hCG)

A

Gonadotropin:Luteinzing hormone (LH) analog

49
Q

Choriogonadotropin alpa

A

Gonadotropin:Luteinzing hormone (LH) analog

Recombiant form of hCG

50
Q

Lutropin

A

Gonadotropin:Luteinzing hormone (LH) analog

Recombinant form of human LH

51
Q

Menotropins (hMG)

A

Gonadotropin:Luteinzing hormone (LH) analog

(hMG) :Extract of the urine of postmenopausal women; contains both FSH and LH activity

52
Q

Gonadotropin:Luteinzing hormone (LH) analog

Recombiant form of hCG

A

Choriogonadotropin alpa

53
Q

Gonadotropin:Luteinzing hormone (LH) analog

Recombinant form of human LH

54
Q

Gonadotropin:Luteinzing hormone (LH) analog

(hMG) :Extract of the urine of postmenopausal women; contains both FSH and LH activity

A

Menotropins (hMG)

55
Q

Human chorionic gonadotropin (hCG)

Mechanism of action

A

Agonist at LH receptor

56
Q

Agonist at LH receptor

A

Human chorionic gonadotropin (hCG)

Mechanism of action

57
Q

Human chorionic gonadotropin (hCG)

Effects

A

Mimics effects of endogenous LH

58
Q

Mimics effects of endogenous LH

A

Human chorionic gonadotropin (hCG)

Effects

59
Q

Human chorionic gonadotropin (hCG)

Clinical applications

A

Initiation of ovulation during controlled ovulation hyperstimulation
Ovarian follicle development in women with hypogonadotropic hypogonadism
Male hypogonadotropic hypogonadism

60
Q

Initiation of ovulation during controlled ovulation hyperstimulation
Ovarian follicle development in women with hypogonadotropic hypogonadism
Male hypogonadotropic hypogonadism

A

Human chorionic gonadotropin (hCG)

Clinical applications

61
Q

Human chorionic gonadotropin (hCG)

Toxicity

A

Ovarian hyperstimulation syndrom and multiple pregnancies in women
Gynecomastia in men
Headache, depression, edema in both sexes

62
Q

Ovarian hyperstimulation syndrom and multiple pregnancies in women
Gynecomastia in men
Headache, depression, edema in both sexes

A

Human chorionic gonadotropin (hCG)

Toxicity

Pharma (29 decks)

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