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Pharma > Aminoglycosides > Flashcards

Aminoglycosides Flashcards

0
Q

Gentamicin

A

Aminoglycoside

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1
Q

Aminoglycosides

A 
Gentamicin
Tobramycin
Amikacin
Streptomycin
Neomycin
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2
Q

Tobramycin

A

Aminoglycoside

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3
Q

Amikacin

A

Aminoglycoside

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4
Q

Streptomycin

A

Aminoglycoside

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5
Q

Neomycin

A

Aminoglycoside

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6
Q

Gentamicin
(Aminoglycosides)

Mechanism of action

A

Prevent bacterial protein synthesis by binding to the 30S ribosomal subunit

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7
Q

Prevent bacterial protein synthesis by binding to the 30S ribosomal subunit

A

Gentamicin
(Aminoglycosides)

Mechanism of action

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8
Q

Gentamicin
(Aminoglycosides)

Effects

A

Bactericidal activity agains susceptible bacteria, synergistic effects against gram-positive bacteria when combined with Beta-lactams or vancomycin, concentration-dependent killing and a significant post-antibiotic effect

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9
Q

Bactericidal activity agains susceptible bacteria, synergistic effects against gram-positive bacteria when combined with Beta-lactams or vancomycin, concentration-dependent killing and a significant post-antibiotic effect

A

Gentamicin
(Aminoglycosides)

Effects

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10
Q

Gentamicin
(Aminoglycosides)

Clinical applications

A

Sepsis caused by aerobic gram-negative bacteria, synergistic activity in endocarditis caused by streptococci, staphylococci and enterococci

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11
Q

Sepsis caused by aerobic gram-negative bacteria, synergistic activity in endocarditis caused by streptococci, staphylococci and enterococci

A

Gentamicin
(Aminoglycosides)

Clinical applications

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12
Q

Gentamicin
(Aminoglycosides)

Pharmacokinetics, Toxicities, Interactions

A

IV, renal clearance (half-life 2.5 h) once-daily dosing as effective and may have less toxicity then conventional dosing, TOXICITY: Nephrotoxicity (reverible), ototoxicity (irreversible), neuromuscular blockade

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13
Q

IV, renal clearance (half-life 2.5 h) once-daily dosing as effective and may have less toxicity then conventional dosing, TOXICITY: Nephrotoxicity (reverible), ototoxicity (irreversible), neuromuscular blockade

A

Gentamicin
(Aminoglycosides)

Pharmacokinetics, Toxicities, Interactions

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14
Q

Tobramycin

Quality

A

Intravenous; more active then gentamicin versus Pseudomonas; may also have less nephrotoxicity

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15
Q

Intravenous; more active then gentamicin versus Pseudomonas; may also have less nephrotoxicity

A

Tobramycin

Quality

16
Q

Amikacin

Quality

A

Intravenous; resistant to many ezymes that inactivate gentamicin and tobramycin; higher doses and target peak and troughs than gentamicin and tobramycin

17
Q

Intravenous; resistant to many ezymes that inactivate gentamicin and tobramycin; higher doses and target peak and troughs than gentamicin and tobramycin

A

Amikacin

Quality

18
Q

Streptomycin

Quality

A

Intramuscular; widespread resistance limits use to specific indications such as tuberculosis and enterococcal endocarditis

19
Q

Intramuscular; widespread resistance limits use to specific indications such as tuberculosis and enterococcal endocarditis

A

Streptomycin

Quality

20
Q

Neomycin

Quality

A

Oral or topical, poor bioavailability; used before bowel surgery to decrease aerobic flora; also used to treat hepatic encephalopathy

21
Q

Oral or topical, poor bioavailability; used before bowel surgery to decrease aerobic flora; also used to treat hepatic encephalopathy

A

Neomycin

Quality

22
Q

Spectinomycin

Quality

A

Intramuscular; sole use is for treatment of antibiotic-resistant gonococcal infections or gonococcal infections in penicillin-allergic patients

23
Q

Intramuscular; sole use is for treatment of antibiotic-resistant gonococcal infections or gonococcal infections in penicillin-allergic patients

A

Spectinomycin

Quality

Pharma (29 decks)

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