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Antipsychotic Drugs & Lithium Flashcards

0
Q

Chlorpromazine

A

Phenothiazine

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1
Q

Phenothiazines

A

Chlorpromazine
Fluphenazine
Thioridazine

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2
Q

Fluphenazine

A

Phenothiazine

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3
Q

Thioridazine

A

Phenothiazine

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4
Q

Chlorpromazine
Fluphenazine
Thioridazine
(Phenothiazines)

Mechanism of action

A

Blockade of D2 receptors&raquo_space; 5-HT2A receptors

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5
Q

Blockade of D2 receptors&raquo_space; 5-HT2A receptors

A

Chlorpromazine, Fluphenazine, Thioridazine, (Phenothiazines)
Thiothixene, (Thioxanthene)
Haloperidol, (Butyrophenone)

Mechanism of action

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6
Q

Chlorpromazine
Fluphenazine
Thioridazine
(Phenothiazines)

Effects

A 
a-Receptor blockade
Muscarinic (M)-receptor blockade
H1-receptor blockade
CNS depression (sedation)
Decreased seizure threshold
QT prolongation
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7
Q 
a-Receptor blockade
Muscarinic (M)-receptor blockade
H1-receptor blockade
CNS depression (sedation)
Decreased seizure threshold
QT prolongation
A 
Chlorpromazine
Fluphenazine
Thioridazine
(Phenothiazines)
Thiothixene
Effects
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8
Q 
Chlorpromazine
Fluphenazine
Thioridazine
(Phenothiazines)
Thiothixene
Clinical applications
A

PSYCHIATRIC: schizophrenia (alleviate positive symptoms), bipolar disorder (manic phase) NONPSYCHIATRIC: antiemesis, preoperative sedation (promethazine), pruritus

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9
Q

PSYCHIATRIC: schizophrenia (alleviate positive symptoms), bipolar disorder (manic phase) NONPSYCHIATRIC: antiemesis, preoperative sedation (promethazine), pruritus

A

Chlorpromazine
Fluphenazine
Thioridazine
(Phenothiazines)

Clinical applications

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10
Q 
Chlorpromazine
Fluphenazine
Thioridazine
(Phenothiazines)
Thiothixene
Pharmacokinetics, Toxicities, Interactions
A

Oral and parenteral forms, long half-lifes with metabolism-dependent elimination, TOXICITY: extensions of effects on Alpha and M- receptors, blockade of dopamine receptors may result in akathisia, dystonia, parkinsonian symptoms, tardive dyskinesia, and hyperprolactinemia

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11
Q

Oral and parenteral forms, long half-lifes with metabolism-dependent elimination, TOXICITY: extensions of effects on Alpha and M- receptors, blockade of dopamine receptors may result in akathisia, dystonia, parkinsonian symptoms, tardive dyskinesia, and hyperprolactinemia

A

Chlorpromazine
Fluphenazine
Thioridazine
(Phenothiazines)

Pharmacokinetics, Toxicities, Interactions

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12
Q

Thiothixene

A

Thioxanthene

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13
Q

Thioxanthene

A

Thiothixene

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14
Q

Thiothixene

Mechanism of action

A

Blockade of D2 receptors&raquo_space; 5-HT2A receptors

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15
Q

Thiothixene

Effects

A 
a-Receptor blockade
Muscarinic (M)-receptor blockade
H1-receptor blockade
CNS depression (sedation)
Decreased seizure threshold
QT prolongation
16
Q

Thiothixene

Clinical applications

A

PSYCHIATRIC: schizophrenia (alleviate positive symptoms), bipolar disorder (manic phase) NONPSYCHIATRIC: antiemesis, preoperative sedation (promethazine), pruritus

17
Q

Thiothixene

Pharmacokinetics, Toxicities, Interactions

A

Oral and parenteral forms, long half-lifes with metabolism-dependent elimination, TOXICITY: extensions of effects on Alpha and M- receptors, blockade of dopamine receptors may result in akathisia, dystonia, parkinsonian symptoms, tardive dyskinesia, and hyperprolactinemia

18
Q

Butyrophenone

A

Haloperidol

19
Q

Haloperidol

A

Butyrophenone

20
Q

Haloperidol

Mechanism of action

A

Blockade of D2 receptors&raquo_space; 5-HT2A receptors

21
Q

Haloperidol

Effects

A

Some Alpha blockade, but minimal M-receptor blockade and much less sedation than the phenothiazines

22
Q

Some Alpha blockade, but minimal M-receptor blockade and much less sedation than the phenothiazines

A

Haloperidol

Effects

23
Q

Haloperidol

Clinical applications

A

Schizophrenia (alleviate positive symptoms), bipolar disorder (manic phase), Huntington’s chorea, Tourette’s syndrome

24
Q

Schizophrenia (alleviate positive symptoms), bipolar disorder (manic phase), Huntington’s chorea, Tourette’s syndrome

A

Haloperidol

Clinical applications

25
Q

Haloperidol

Pharmacokinetics, Toxicities, Interactions

A

Oral and parenteral forms with metabolism-dependent elimination, TOXICITY: extrapyramidal dysfunction is a major adverse effect

26
Q

Oral and parenteral forms with metabolism-dependent elimination, TOXICITY: extrapyramidal dysfunction is a major adverse effect

A

Haloperidol

Pharmacokinetics, Toxicities, Interactions

27
Q

Atypical antipsychotics

A 
Aripiprazole
Clozapine
Olanzapine
Quetiapine
Risperidone
Ziprasidone
28
Q

Aripiprazole

A

Atypical antipsychotic

29
Q

Clozapine

A

Atypical antipsychotic

30
Q

Olanzapine

A

Atypical antipsychotic

31
Q

Quetiapine

A

Atypical antipsychotic

32
Q

Risperidone

A

Atypical antipsychotic

33
Q

Risperidone

A

Atypical antipsychotic

34
Q

Blockade of 5-HT2A receptors > blockade of D2 receptors

A

Aripiprazole
Clozaine
Risperidone
(atypical antipsychotic)

Mechanism of action

35
Q

Aripiprazole
Clozaine
Risperidone
(atypical antipsychotic)

Mechanism of action

A

Blockade of 5-HT2A receptors > blockade of D2 receptors

36
Q

Aripiprazole
Clozaine
Risperidone
(atypical antipsychotic)

Clinical applications

A

Schizophrenia- improve both positive and negative symptoms, bipolar disorder (olanzapine or risperidone adjunctive with lithium), agitation in Alzheimer’s and Parkinson’s patients (low doses), major depression (aripiprazole)

37
Q

Schizophrenia- improve both positive and negative symptoms, bipolar disorder (olanzapine or risperidone adjunctive with lithium), agitation in Alzheimer’s and Parkinson’s patients (low doses), major depression (aripiprazole)

A

Aripiprazole
Clozaine
Risperidone
(atypical antipsychotic)

Clinical applications

Pharma (29 decks)

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