Antipsychotic Drugs & Lithium

Question 0

Chlorpromazine

Answer 0

Phenothiazine

Question 1

Phenothiazines

Answer 1

Chlorpromazine
Fluphenazine
Thioridazine

Question 2

Fluphenazine

Answer 2

Phenothiazine

Question 3

Thioridazine

Answer 3

Phenothiazine

Question 4

Chlorpromazine
Fluphenazine
Thioridazine
(Phenothiazines)

Mechanism of action

Answer 4

Blockade of D2 receptors&raquo_space; 5-HT2A receptors

Question 5

Blockade of D2 receptors&raquo_space; 5-HT2A receptors

Answer 5

Chlorpromazine, Fluphenazine, Thioridazine, (Phenothiazines)
Thiothixene, (Thioxanthene)
Haloperidol, (Butyrophenone)

Mechanism of action

Question 6

Chlorpromazine
Fluphenazine
Thioridazine
(Phenothiazines)

Effects

Answer 6

a-Receptor blockade
Muscarinic (M)-receptor blockade
H1-receptor blockade
CNS depression (sedation)
Decreased seizure threshold
QT prolongation

Question 7

a-Receptor blockade
Muscarinic (M)-receptor blockade
H1-receptor blockade
CNS depression (sedation)
Decreased seizure threshold
QT prolongation

Answer 7

Chlorpromazine
Fluphenazine
Thioridazine
(Phenothiazines)
Thiothixene
Effects

Question 8

Chlorpromazine
Fluphenazine
Thioridazine
(Phenothiazines)
Thiothixene
Clinical applications

Answer 8

PSYCHIATRIC: schizophrenia (alleviate positive symptoms), bipolar disorder (manic phase) NONPSYCHIATRIC: antiemesis, preoperative sedation (promethazine), pruritus

Question 9

PSYCHIATRIC: schizophrenia (alleviate positive symptoms), bipolar disorder (manic phase) NONPSYCHIATRIC: antiemesis, preoperative sedation (promethazine), pruritus

Answer 9

Chlorpromazine
Fluphenazine
Thioridazine
(Phenothiazines)

Clinical applications

Question 10

Chlorpromazine
Fluphenazine
Thioridazine
(Phenothiazines)
Thiothixene
Pharmacokinetics, Toxicities, Interactions

Answer 10

Oral and parenteral forms, long half-lifes with metabolism-dependent elimination, TOXICITY: extensions of effects on Alpha and M- receptors, blockade of dopamine receptors may result in akathisia, dystonia, parkinsonian symptoms, tardive dyskinesia, and hyperprolactinemia

Question 11

Oral and parenteral forms, long half-lifes with metabolism-dependent elimination, TOXICITY: extensions of effects on Alpha and M- receptors, blockade of dopamine receptors may result in akathisia, dystonia, parkinsonian symptoms, tardive dyskinesia, and hyperprolactinemia

Answer 11

Chlorpromazine
Fluphenazine
Thioridazine
(Phenothiazines)

Pharmacokinetics, Toxicities, Interactions

Question 12

Thiothixene

Answer 12

Thioxanthene

Question 13

Thioxanthene

Answer 13

Thiothixene

Question 14

Thiothixene

Mechanism of action

Answer 14

Blockade of D2 receptors&raquo_space; 5-HT2A receptors

Question 15

Thiothixene

Effects

Answer 15

a-Receptor blockade
Muscarinic (M)-receptor blockade
H1-receptor blockade
CNS depression (sedation)
Decreased seizure threshold
QT prolongation

Question 16

Thiothixene

Clinical applications

Answer 16

PSYCHIATRIC: schizophrenia (alleviate positive symptoms), bipolar disorder (manic phase) NONPSYCHIATRIC: antiemesis, preoperative sedation (promethazine), pruritus

Question 17

Thiothixene

Pharmacokinetics, Toxicities, Interactions

Answer 17

Oral and parenteral forms, long half-lifes with metabolism-dependent elimination, TOXICITY: extensions of effects on Alpha and M- receptors, blockade of dopamine receptors may result in akathisia, dystonia, parkinsonian symptoms, tardive dyskinesia, and hyperprolactinemia

Question 18

Butyrophenone

Answer 18

Haloperidol

Question 19

Haloperidol

Answer 19

Butyrophenone

Question 20

Haloperidol

Mechanism of action

Answer 20

Blockade of D2 receptors&raquo_space; 5-HT2A receptors

Question 21

Haloperidol

Effects

Answer 21

Some Alpha blockade, but minimal M-receptor blockade and much less sedation than the phenothiazines

Question 22

Some Alpha blockade, but minimal M-receptor blockade and much less sedation than the phenothiazines

Answer 22

Haloperidol

Effects

Question 23

Haloperidol

Clinical applications

Answer 23

Schizophrenia (alleviate positive symptoms), bipolar disorder (manic phase), Huntington’s chorea, Tourette’s syndrome

Question 24

Schizophrenia (alleviate positive symptoms), bipolar disorder (manic phase), Huntington's chorea, Tourette's syndrome

Answer 24

Haloperidol Clinical applications

Question 25

Haloperidol Pharmacokinetics, Toxicities, Interactions

Answer 25

Oral and parenteral forms with metabolism-dependent elimination, TOXICITY: extrapyramidal dysfunction is a major adverse effect

Question 26

Oral and parenteral forms with metabolism-dependent elimination, TOXICITY: extrapyramidal dysfunction is a major adverse effect

Answer 26

Haloperidol Pharmacokinetics, Toxicities, Interactions

Question 27

Atypical antipsychotics

Answer 27

``` Aripiprazole Clozapine Olanzapine Quetiapine Risperidone Ziprasidone ```

Question 28

Aripiprazole

Answer 28

Atypical antipsychotic

Question 29

Clozapine

Answer 29

Atypical antipsychotic

Question 30

Olanzapine

Answer 30

Atypical antipsychotic

Question 31

Quetiapine

Answer 31

Atypical antipsychotic

Question 32

Risperidone

Answer 32

Atypical antipsychotic

Question 33

Risperidone

Answer 33

Atypical antipsychotic

Question 34

Blockade of 5-HT2A receptors > blockade of D2 receptors

Answer 34

Aripiprazole Clozaine Risperidone (atypical antipsychotic) Mechanism of action

Question 35

Aripiprazole Clozaine Risperidone (atypical antipsychotic) Mechanism of action

Answer 35

Blockade of 5-HT2A receptors > blockade of D2 receptors

Question 36

Aripiprazole Clozaine Risperidone (atypical antipsychotic) Clinical applications

Answer 36

Schizophrenia- improve both positive and negative symptoms, bipolar disorder (olanzapine or risperidone adjunctive with lithium), agitation in Alzheimer's and Parkinson's patients (low doses), major depression (aripiprazole)

Question 37

Schizophrenia- improve both positive and negative symptoms, bipolar disorder (olanzapine or risperidone adjunctive with lithium), agitation in Alzheimer's and Parkinson's patients (low doses), major depression (aripiprazole)

Answer 37

Aripiprazole Clozaine Risperidone (atypical antipsychotic) Clinical applications