Cancer Chemotherapy

Question 0

Cyclophosphamide

Answer 0

Alkylating agent
Cytotoxic effect via transfer of alkyl groups to various cellular constitutents
Cell-cycle-nonspecific (CCNS) agent

Question 1

Alkylating agent
Cytotoxic effect via transfer of alkyl groups to various cellular constitutents
Cell-cycle-nonspecific (CCNS) agent

Answer 1

Cyclophosphamide

Question 2

Recombinant humanized monoclonial antibody that targets all forms of VEGF-A

Anti angiogenic

Answer 2

Bevacizumab

Question 3

Bevacizumab

Answer 3

Recombinant humanized monoclonial antibody that targets all forms of VEGF-A

Anti angiogenic

Question 4

Infliximab

Answer 4

Human-mouse chineric IgG1 monoclonial antibody

Bind TNF-a, ( a proinflamatory cytokine importent in inflammatory diseases)

Question 5

Human-mouse chineric IgG1 monoclonial antibody

Bind TNF-a, ( a proinflamatory cytokine importent in inflammatory diseases)

Answer 5

Infliximab

Question 6

Anakinra

Answer 6

Recombinant form of IL-1 receptor antagonist

Question 7

Recombinant form of IL-1 receptor antagonist

Answer 7

Anakinra

Question 8

Oxaliplatin

Answer 8

3rd generation platinum analog
Cytotoxic effect similar to alkylating agent, kill tumor cells in all stages of the cell cycle and bind DNA by forming intrastrand and interstrand cross-links, inhibiting DNA synthesis

Question 9

3rd generation platinum analog
Cytotoxic effect similar to alkylating agent, kill tumor cells in all stages of the cell cycle and bind DNA by forming intrastrand and interstrand cross-links, inhibiting DNA synthesis

Answer 9

Oxaliplatin

Question 10

5-Fluorouracil (5-FU)

Answer 10

Fluoropyrimidine
Anti-metabolite, interferes with DNA and RNA syntesis
Most widely used agent in the treatment of colorectal cancer

Question 11

Fluoropyrimidine
Anti-metabolite, interferes with DNA and RNA syntesis
Most widely used agent in the treatment of colorectal cancer

Answer 11

5-Fluorouracil (5-FU)

Question 12

Vincristine

Answer 12

Alkaloid derived from the plant Vinca rosea
Inhibits tubulin polymerization, leads to mitotic arrest in metaphase
Cell-cycle-specific (CCS) agent

Hematologic malignancies

Question 13

Alkaloid derived from the plant Vinca rosea
Inhibits tubulin polymerization, leads to mitotic arrest in metaphase
Cell-cycle-specific (CCS) agent

Hematologic malignancies

Answer 13

Vincristine

Question 14

Paclitaxel

Answer 14

Alkaloid ester derrived from Taxus brevifolia and Taxus baccata
Mitotic spindle poison

Solid tumors

Question 15

Alkaloid ester derrived from Taxus brevifolia and Taxus baccata
Mitotic spindle poison

Solid tumors

Answer 15

Paclitaxel

Question 16

Etoposide

Answer 16

Epipodophyllotoxin
Inhibition of topoisomerase II

Small cell cancer, etc

Question 17

Epipodophyllotoxin
Inhibition of topoisomerase II

Small cell cancer, etc

Answer 17

Etoposide

Question 18

Doxorubicin

Answer 18

Anthracycline
Cytotoxic antcancer drug
Inhibits topoisomerase II, bind DNA, free radical production, bind cellular membranes

Question 19

Anthracycline
Cytotoxic antcancer drug
Inhibits topoisomerase II, bind DNA, free radical production, bind cellular membranes

Answer 19

Doxorubicin