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Pharma > Agent Used In Anemias & Hematopoietic Growth Factors > Flashcards

Agent Used In Anemias & Hematopoietic Growth Factors Flashcards

0
Q

Oral iron preperations

A

Ferrous gluconate

Ferrous fumarate

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1
Q

Iron

A 
Ferrous sulfate
Ferrous gluconate
Ferrous fumarate
Iron dextran
Iron sucrose complex
Sodium ferric gluconate complex
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2
Q

Ferrous gluconate

Ferrous fumarate

A

Oral iron preperations

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3
Q

Iron dextran
Iron sucrose complex
Sodium ferric gluconate complex

A

Parenteral preparation; can cause pain, hypersensitivity reactions

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4
Q

Parenteral preparation; can cause pain, hypersensitivity reactions

A

Iron dextran
Iron sucrose complex
Sodium ferric gluconate complex

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5
Q

Ferrous sulfate

Mechanism of action

A

Required for biosynthesis of heme and heme-containing proteins, including hemoglobin and myoglobin

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6
Q

Ferrous sulfate

Mechanism of action

A

Required for biosynthesis of heme and heme-containing proteins, including hemoglobin and myoglobin

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7
Q

Ferrous sulfate

Effects

A

Adequate supplies required for normal heme synthesis

Deficiency results in inadequate heme production

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8
Q

Adequate supplies required for normal heme synthesis

Deficiency results in inadequate heme production

A

Ferrous sulfate

Effects

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9
Q

Ferrous sulfate

Clinical applications

A

Iron deficiency, which manifests as microcytic anemia

Oral preparation

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10
Q

Ferrous sulfate

Effects

A

Ferrous sulfate

Clinical applications

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11
Q

Ferrous sulfate

Toxicity

A

Acute overdose results in necrotizing gastroenteritis, abdominal pain, bloody diarrhea, shock, lethargy, and dyspnea
Chronic iron overload results in hemochromatosis, with damage to the heart, liver, pancreas, and other organs
Orgen failure and death can ensue

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12
Q

Acute overdose results in necrotizing gastroenteritis, abdominal pain, bloody diarrhea, shock, lethargy, and dyspnea
Chronic iron overload results in hemochromatosis, with damage to the heart, liver, pancreas, and other organs
Orgen failure and death can ensue

A

Ferrous sulfate

Toxicity

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13
Q

Iron chelators

A

Deferoxamine

Deferasirox

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14
Q

Deferoxamine

A

Iron chelator

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15
Q

Deferasirox

A

Iron chelator

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16
Q

Deferasirox

Usage

A

Orally administered iron chelator for treatment of hemochromatosis

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17
Q

Orally administered iron chelator for treatment of hemochromatosis

A

Deferasirox

Usage

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18
Q

Deferoxamine

Mechanism of action

A

Chelates excess iron

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19
Q

Chelates excess iron

A

Deferoxamine

Mechanism of action

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20
Q

Deferoxamine

Effects

A

Reduces toxicity associated with acute or chronic iron overload

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21
Q

Reduces toxicity associated with acute or chronic iron overload

A

Deferoxamine

Effects

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22
Q

Deferoxamine

Clinical applications

A

Acute iron poisoning inherited or acquired hemochromatosis

23
Q

Acute iron poisoning inherited or acquired hemochromatosis

A

Deferoxamine

Clinical applications

24
Q

Deferoxamine

Toxicity

A

Rapid IV administration may cause hypotension

Neurotoxicity and incresed susceptibility to certain infection have occurred with long-term use

25
Q

Rapid IV administration may cause hypotension

Neurotoxicity and incresed susceptibility to certain infection have occurred with long-term use

A

Deferoxamine

Toxicity

26
Q

Vitamin B12

A

Cyanocobalamin

Hydroxocobalamin

27
Q

Hydroxocobalamin

A

Vitamin B12

28
Q

Cyanocobalamin

A

Vitamin B12

29
Q

Cyanocobalamin (vitamin B12)
Hydroxocobalamin (vitamin B12)

Mechanism of action

A

Cofactor required for essential enzymatic reaction that form tetrahydrofolate, coverts homocysteine to methionine, and metabolize L-methylmalonyl-CoA

30
Q

Cofactor required for essential enzymatic reaction that form tetrahydrofolate, coverts homocysteine to methionine, and metabolize L-methylmalonyl-CoA

A

Cyanocobalamin (vitamin B12)
Hydroxocobalamin (vitamin B12)

Mechanism of action

31
Q

Cyanocobalamin (vitamin B12)
Hydroxocobalamin (vitamin B12)

Effects

A

Adequate supplies required for amino acid and fatty acid metabolism, and DNA synthesis

32
Q

Adequate supplies required for amino acid and fatty acid metabolism, and DNA synthesis

A

Cyanocobalamin (vitamin B12)
Hydroxocobalamin (vitamin B12)

Effects

33
Q

Cyanocobalamin (vitamin B12)
Hydroxocobalamin (vitamin B12)

Clinical applications

A

Vitamin B12 deficiency, which manifests as megaloblastic anemia and is the basis for pernicious anemia

34
Q

Vitamin B12 deficiency, which manifests as megaloblastic anemia and is the basis for pernicious anemia

A

Cyanocobalamin (vitamin B12)
Hydroxocobalamin (vitamin B12)

Clinical applications

35
Q

Cyanocobalamin (vitamin B12)
Hydroxocobalamin (vitamin B12)

Toxicity

A

No toxicity associated with excess

36
Q

No toxicity associated with excess

A

Cyanocobalamin (vitamin B12)
Hydroxocobalamin (vitamin B12)

Toxicity

37
Q

Reference range of vitamin B12

A

180-914 ng/L
or
150-900 pg/mL

38
Q

180-914 ng/L
or
150-900 pg/mL

A

Reference range of vitamin B12

39
Q

Folic acid

A

Folacin (pteroylglutamic acid)

40
Q

Folacin (pteroylglutamic acid)

A

Folic acid

41
Q

Folacin (pteroylglutamic acid)

Mechanism of action

A

Precursor of an essential donor for methyl groups used for synthesis of amino acids, purines, and deoxynucleotide

42
Q

Precursor of an essential donor for methyl groups used for synthesis of amino acids, purines, and deoxynucleotide

A

Folacin (pteroylglutamic acid)

Mechanism of action

43
Q

Folacin (pteroylglutamic acid)

Effects

A

Adequate supplies required for essential biochemical reactions involving amino acid metabolism, and purine and DNA synthesis

44
Q

Adequate supplies required for essential biochemical reactions involving amino acid metabolism, and purine and DNA synthesis

A

Folacin (pteroylglutamic acid)

Effects

45
Q

Erythrocyte-stimulating agents

A

Epoetin alfa
Darbepoetin alfa
Methoxy polyethylene glycol-epoetin beta

46
Q

Darbepoetin alfa

A

Erythrocyte-stimulating agent

47
Q

Methoxy polyethylene glycol-epoetin beta

A

Erythrocyte-stimulating agent

48
Q

Epoetin alfa

A

Erythrocyte-stimulating agent

49
Q

Epoetin alfa

Mechanism of action

A

Agonist of erythropoietin receptors expressed by red cell progenitors

50
Q

Agonist of erythropoietin receptors expressed by red cell progenitors

A

Epoetin alfa

Mechanism of action

51
Q

Epoetin alfa

Effects

A

Stimulates erythroid proliferation and differentiation, and induces the release of reticulocytes from bone marrow

52
Q

Stimulates erythroid proliferation and differentiation, and induces the release of reticulocytes from bone marrow

A

Epoetin alfa

Effects

53
Q

Epoetin alfa

Clinical applications

A

Anemia, especially anemia associated with chronic renal failure, HIV infection, cancer and prematurity
Prevention of the need for transfusion in patients undergoing certain types of elective surgery

54
Q

Anemia, especially anemia associated with chronic renal failure, HIV infection, cancer and prematurity
Prevention of the need for transfusion in patients undergoing certain types of elective surgery

A

Epoetin alfa

Clinical applications

55
Q

Epoetin alfa

Toxicity

A

Hypertension, thrombotic complications, and very rarely, pure red cell aplasia

56
Q

Hypertension, thrombotic complications, and very rarely, pure red cell aplasia

A

Epoetin alfa

Toxicity

Pharma (29 decks)

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