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Drugs Used In Thyroid Disease Flashcards

0
Q

Levothyroxine (T4)

A

Thyroid preperation

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1
Q

Thyroid preperations

A

Levothyroxine (T4)

Liothyronine (T3)

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2
Q

Liothyronine (T3)

A

Thyroid preperation

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3
Q

Levothyroxine (T4)

Mechanism of action and effects

A

Activation of nuclear receptors results in gene expression with RNA formation and protein synthesis

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4
Q

Activation of nuclear receptors results in gene expression with RNA formation and protein synthesis

A

Levothyroxine (T4)

Mechanism of action and effects

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5
Q

Levothyroxine (T4)

Indications

A

Hypothyroidism

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6
Q

Hypothyroidism

A

Levothyroxine (T4)

Indications

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7
Q

Antithyroid agents (thioamides)

A

Methimazole

Propylthiouracil (PTU)

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8
Q

Propylthiouracil (PTU)

A

Antithyroid agent (thioamide)

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9
Q

Methimazole

A

Antithyroid agent (thioamide)

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10
Q

Methimazole
Propylthiouracil (PTU)

Mechanism of action and effects

A

Inhibit thyroid peroxidase reaction
Block iodine organification
Inhibit perpheral deiodination of T4 and T3 (primarily PTU)

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11
Q

Inhibit thyroid peroxidase reaction
Block iodine organification
Inhibit perpheral deiodination of T4 and T3 (primarily PTU)

A

Methimazole
Propylthiouracil (PTU)

Mechanism of action and effects

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12
Q

Methimazole
Propylthiouracil

Indications

A

Hyperthyroidism

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13
Q

Hyperthyroidism

A

Methimazole
Propylthiouracil

Indications

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14
Q

Methimazole
Propylthiouracil

Toxicity

A 
Nausea
Gastrointestinal distress
Rash
Agranulocytosis
Hepatitis
(PTU black box)
Hypothyroidism
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15
Q 
Nausea
Gastrointestinal distress
Rash
Agranulocytosis
Hepatitis
(PTU black box)
Hypothyroidism
A

Methimazole
Propylthiouracil

Toxicity

16
Q

Iodides

A

Lugol solution

Potassium iodide

17
Q

Lugol solution

18
Q

Potassium iodide

19
Q

Lugol solution
Potassium iodide

Mechanism of action and effects

A

Inhibits organification and hormone release

Reduce the size and vascularity of the gland

20
Q

Inhibits organification and hormone release

Reduce the size and vascularity of the gland

A

Lugol solution
Potassium iodide

Mechanism of action and effects

21
Q

Lugol solution
Potassium iodide

Indications

A

Preperation for surgical thyroidectomy

22
Q

Preperation for surgical thyroidectomy

A

Lugol solution
Potassium iodide

Indications

23
Q

Beta blocker

A

Propranolol

24
Q

Propranolol

A

Beta blocker

25
Q

Propranolol

Mechanism of action and effects (in thyroid disease)

A

Inhibition of Beta adrenoreceptors

Inhibit T4 to T3 conversion (only propranolol)

26
Q

Inhibition of Beta adrenoreceptors

Inhibit T4 to T3 conversion

A

Propranolol

Mechanism of action and effect ( in thyroid disease)

27
Q

Propranolol

Indication (in thyroid disease)

A

Hyperthyroidism, especially thyroid storm

Adjunct to control tachcardia, hypertension and atrial fibrillation

28
Q

Hyperthyroidism, especially thyroid storm

Adjunct to control tachcardia, hypertension and atrial fibrillation

A

Propranolol

Indication (in thyroid disease)

29
Q

Propranolol

Toxicity (in thyroid disease)

A

Asthma
AV blockade
Hypotension
Bradycardia

30
Q

Asthma
AV blockade
Hypotension
Bradycardia

A

Propranolol

Toxicity (in thyroid disease)

31
Q

Radioactive iodine 131 I (RAI)

Mechanism of action and effects

A

Radiation destruction of thyroid parenchyma

32
Q

Radiation destruction of thyroid parenchyma

A

Radioactive iodine 131 I (RAI)

Mechanism of action and effects

33
Q

Radioactive iodine 131 I (RAI)

Indications

A

Hyperthyroidism
Patients should be euthyroid or on Beta blockers before RAI
Avoid in pregnancy or in nursing mothers

34
Q

Hyperthyroidism
Patients should be euthyroid or on Beta blockers before RAI
Avoid in pregnancy or in nursing mothers

A

Radioactive iodine 131 I (RAI)

Indications

35
Q

Radioactive iodine 131 I (RAI)

Toxicity

A

Sore throat
Sialitis
Hypothyroidism

36
Q

Sore throat
Sialitis
Hypothyroidism

A

Radioactive iodine 131 I (RAI)

Toxicity

Pharma (29 decks)

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