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Drugs Used In Disorders Of Coagulation Flashcards

0
Q

Unfractionated heparin (UFH)

A

Indirect thrombin inhibitor

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1
Q

Indirect thrombin inhibitors

A

Unfractionated heparin (UFH)
Low-molecular-weight heparin (LMWH)
Fondaparinux

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2
Q

Low-molecular-weight heparin (LMWH)

A

Indirect thrombin inhibitor

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3
Q

Fondaparinux

A

Indirect thrombin inhibitor

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4
Q

Antithrombin lll

A

Endogenous anticoagulant

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5
Q

Antithrombin lll

Actions

A

Antithrombin inhibits clotting factor proteases, especially thrombin (lla), lXa, and Xa, by forming equimolar stable complexes with them. In the absence of heparin, these reactions are slow; in presence of heparin, they are accelerated 1000-fold.

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6
Q

inhibits clotting factor proteases, especially thrombin (lla), lXa, and Xa, by forming equimolar stable complexes with them. In the absence of heparin, these reactions are slow; in presence of heparin, they are accelerated 1000-fold.

A

Antithrombin lll

Actions

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7
Q

LMW heparins

A

Enoxaparin
Dalteparin
Tinzaparin

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8
Q

Enoxaparin

A

LMW heparin

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9
Q

Dalteparin

A

LMW heparin

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10
Q

Tinzaparin

A

LMW heparin

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11
Q

Protamine sulfate

Usage

A

Antagonist of heparin

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12
Q

Antagonist of heparin

A

Protamine sulfate

Usage

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13
Q

Oral direct factor Xa inhibitors

A

Rivaroxaban

Apixaban

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14
Q

Apixaban

A

Oral direct factor Xa inhibitor

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15
Q

Rivaroxaban

A

Oral direct factor Xa inhibitor

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16
Q

Rivaroxaban
Apixaban

Actions

A

Inhibit factor Xa, in the final common pathway of clotting

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17
Q

Inhibit factor Xa, in the final common pathway of clotting

A

Rivaroxaban
Apixaban

Actions

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18
Q

Direct thrombin inhibitors (DTIs)

A 
Hirudin
Bivalirudin
Argatroban
Melagatran
Dabigatran etexilate mesylate
19
Q

Parenteral direct thrombin inhibitors (DTIs)

A

Hirudin
Lepirudin
Bivalirudin
Argatronan

20
Q

Hirudin

A

Parenteral direct thrombin inhibitor (DTI)

21
Q

Lepirudin

A

Parenteral direct thrombin inhibitor (DTI)

22
Q

Bivalirudin

A

Parenteral direct thrombin inhibitor (DTI)

23
Q

Argatronan

A

Parenteral direct thrombin inhibitor (DTI)

24
Q

Oral direct thrombin inhibitor (DTI

A

Dabigatran etexilate mesylate

25
Q

Dabigatran etexilate mesylate

A

Oral direct thrombin inhibitor (DTI

26
Q

Fibrinolytic drugs

A 
Streptokinase
Urokinase
Alteplase
Reteplase
Tenecteplace
27
Q

Streptokinase

A

Fibrinolytic drug

28
Q

Urokinase

A

Fibrinolytic drug

29
Q

Alteplase

A

Fibrinolytic drug (Manufactured human t-PA)

30
Q

Tenecteplace

A

Fibrinolytic drug (Manufactured human t-PA)

31
Q

Reteplase

A

Fibrinolytic drug (Manufactured human t-PA)

32
Q

Manufactured human t-PA

A

Alteplase
Reteplase
Tenecteplace

33
Q

Fibrolytic drugs

Indications

A

Pulmonary embolism with hemodynamic instability
Severe deep venous thrombus
Ascending thrombophlebitis
(Acute myocardial infarction, depends on circumstances)

34
Q

Pulmonary embolism with hemodynamic instability
Severe deep venous thrombus
Ascending thrombophlebitis
(Acute myocardial infarction, depends on circumstances)

A

Fibrolytic drugs

Indications

35
Q

Antiplatelet agents

A 
Aspirin
Ticlopidine
Clopidogrel
Prasugrel
Abciximab
Eptifibatide
Tirofiban
Dipyridamole
Cilostazol
36
Q

Aspirin

A

Antiplatelet agent (cyclooxygenase inhibitor)

37
Q

Ticlopidine

A

Antiplatelet agent (ADP pathway inhibitor)

38
Q

Clopidogrel

A

Antiplatelet agent (ADP pathway inhibitor)

39
Q

Prasugrel

A

Antiplatelet agent (ADP pathway inhibitor)

40
Q

Abciximab

A

Antiplatelet agent (glycoprotein llb/llla inhibitor)

41
Q

Eptifibatide

A

Antiplatelet agent (glycoprotein llb/llla inhibitor)

42
Q

Tirofiban

A

Antiplatelet agent (glycoprotein llb/llla inhibitor)

43
Q

Antiplatelet agents (glycoprotein llb/llla inhibitors)

A

Abciximab
Eptifibatide
Tirofiban

44
Q

Antiplatelet agents (ADP pathway inhibitors)

A

Ticlopidine
Clopidogrel
Prasugrel

45
Q

Aminocaproic acid

A

Clinically useful inhibitor of fibrinolysis

46
Q

Clinically useful inhibitor of fibrinolysis

A

Aminocaproic acid

Pharma (29 decks)

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