Student Seminars 9/11- Sickle cell Flashcards
1
Q
Hereditary anemia
A
: not enough healthy RBCs to carry oxygen to the body’s tissues
2
Q
Hemoglobin function
A
-Transports: Oxygen, Carbon dioxide
-Two-way respiratory carrier
3
Q
Hemoglobin structure
A
4 subunits:
Polypeptide chain(alpha/ beta)
Heme groups( holds iron+ where oxygen binds)
4
Q
hemoglobin structure mutation
A
beta chains
single-point mutation on beta chain gene
5
Q
normal aa for beta chains
A
GAG– glutamate which is hydrophillic
6
Q
mutated aa for beta chains
A
GTG– valine which is hydrophobic
7
Q
what happens when val is exposed to blood
A
another beta chain tries binds to cover hydrophobic motif–> cycle continues
8
Q
systemic impact
A
Stuck RBCs
WBC aggregates
Vaso occlusion
Tissue ischemia
9
Q
immune system impact
A
Due to systemic issues, the body mounts an inflammatory response
