Preeclampsia/eclampsia

Question 1

preeclampsia

Answer 1

A serious and potentially life-
threatening high blood pressure
condition in pregnancy and/or
postpartum

Question 2

eclampsia

Answer 2

A serious complication of preeclampsia that results in seizures either in pregnancy or postpartum.

Question 3

spiral artery remodeling 1

Answer 3

Early changes in the vessel wall, with
endothelial cells swelling and individual smooth muscle cells becoming enlarged.

Question 4

spiral artery remodeling 2

Answer 4

Extravillous trophoblasts (EVTs) from the placenta start to invade the tissue
surrounding the spiral artery, disrupting the smooth muscle layer.

Question 5

spiral artery remodeling 3

Answer 5

EVTs actively penetrate the vessel wall, entering the lumen of the spiral artery

Question 6

spiral artery remodeling 4

Answer 6

The invading trophoblasts become
embedded within the vessel wall,
forming a fibrinoid layer that replaces
the muscular wall.

Question 7

spiral artery remodeling 5

Answer 7

The remodeled spiral artery is re-lined with new endothelium and a thickened subintimal layer containing
myofibroblasts.

Question 8

spiral artery in pregnancy

Answer 8

extremely dilated to get better blood supply to baby

Question 9

patho of preeclampsia

Answer 9

Failure of trophoblasts to invade and remodel the uterine blood vessels

Question 10

preeclampsia cell specifics

Answer 10

1. Improper recruitment of
   trophoblasts
2. Improper trophoblast and
   cell differentiation
3. Defective maturation of
   endothelial and NK cells

Question 11

Decreased Placental Perfusion mother response

Answer 11

1. Inflammatory Response
2. Decreased blood supply to
   the fetus
   3.Proteins Released
3. Endothelial Cell Damage
   >Increased permeability ->edema
   >Narrowing of vessels -> HTN
   >Thrombi Formation
   >Retention of Na+ in kidneys ->
   proteinuria

Question 12

HELLP Syndrome

Answer 12

Hemolysis,
Elevated Liver
enzymes, Low
Platelet coun