IBD Flashcards
Inflammatory Bowel Disease
disorders involving chronic inflammation of tissues within the digestive tract
possible causes for IBD
Immune System Malfunction
genetic mutation
risk factors
age
race
smoking
nsaids
ulcerative colitis classified as
autoimmune disease
affects which organs/ layers
large intestine only
mucosa and submucosa
ulcers
areas in mucosa where tissue has been eaten away by the inflammation leaving open sores in the membrane.
ulcerative colitis 1
T-cells destroy cells lining the walls of the large intestine leaving eroded areas called ulcers
ulcerative colitis 2
pANCAs target the body’s own antigens that are within the neutrophils
- This is thought to be from an immune reaction to our own gut bacteria that are structurally similar to something else
ulcerative colitis 3
A cross reaction happens which produces sulfide
ulcerative colitis 4
The increase in sulfide will help to cause inflammation
Crohn’s disease def
a chronic inflammatory disease that interests the whole GI tract
most common in the small intestine
crohn’s classified as…
immune related disorder
Crohn’s thought to be triggered by which foreign pathogens in the GI
Mycobacterium Paratuberculosis
Pseudomonas
Listeria
genetic mutation
Frameshift Mutation in the NOD2 gene
inflammation cytokines released during inflammation T helper cell
interferon gamma and TNF-alpha
