Renal and Adrenal Cortex Disorders

Question 1

Common kidney disorders

Answer 1

CKD
Kidney Stones
Polycystic Kidney Disease
Glomerulonephritis

Question 1

common adrenal cortex disorders

Answer 1

Cushing’s Syndrome
Addison’s Disease
Adrenocortical Carcinoma
Hyperaldosteronism

Question 2

causes of addison’s

Answer 2

1. Autoimmune disease-in developed countries
2. Tuberculosis-in developing countries
3. Meds that alter glucocorticoid production
4. Metastatic Carcinoma

Question 3

causes of cushing’s

Answer 3

1.Exogenous (cortisol) steroid medications
2. Endogenous cortisol (from tumor)
3. Sporadic mutations (USP8)
4. Adrenal adenomas/carcinomas

Question 4

addison’s mech

Answer 4

decrease in aldosterone (BP), decrease in cortisol (BG), decrease in androgens

Question 5

cushing’s mech

Answer 5

excess cortisol–> several negative manifestations