Intro to inflammation Flashcards
Pathogenesis
determined by the host, infectious agent, and
environment
Physical barrier
- Epithelial tissue
- Microbiome
Chemical barrier
- Mucous
- Oil
- Harsh living
conditions
Innate Immunity
- Natural immunity
- Immediate effect
– Lower potency - Lifelong efficacy
Innate immunity protection
- Physical barriers
- Chemical barriers
- General defenses
Adaptive Immunity
- Acquired immunity
- Effective days to weeks post infection
– Highly effective - Efficacy duration dependent on type
Adaptive immunity protection
- Cell-mediated response
- Active immunity
- Specific defenses
Four signs of inflammation
redness, swelling, pain, heat
inflammation
response to damaged cells/ tissue
inflammation defense mechanism
– Localize injurious agent
– Eliminate injurious agent
– Remove damaged tissue
– Start healing
types of infectious agents
Bacteria, virus, fungus, parasite
Factors that impact infectious ability
– Number of microorganisms
– Ability to enter body
– Host susceptibility
– Viability in host
Approximately 80% of individuals diagnosed with autoimmune
diseases are ___
female
autoimmune disease cause
combination of environmental factors and genetics
– Molecular mimicry, bystander activation, epitope spread
Carrier state
short or long term reservoir with no clinical impact
